Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study


Oğuz Karaca 1 , * , Anıl Avcı 2 , Gamze Babur Güler 1 , Onur Omaygenc 1 , Beytullah Cakal 1 , Haci Murat Gunes 1 , Elnur Alizade 2 , Ali Metin Esen 2 , Irfan Barutcu 2 , Bilal Boztosun 2

1 Department of Cardiology, Faculty of Medicine, Medipol University, Istanbul, Turkey

2 Department of Cardiology, Kartal Koşuyolu Heart and Research Hospital, Istanbul, Turkey

How to Cite: Karaca O , Avcı A , Babur Güler G , Omaygenc O , Cakal B , et al. Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study, Int Cardio Res J. 2016 ; 10(1):e10307.


International Cardiovascular Research Journal: 10 (1); e10307
Published Online: March 01, 2016
Article Type: Research Article
Received: January 17, 2015
Revised: June 22, 2015
Accepted: August 19, 2015


Background: Right Ventricular (RV) functions are known to have an impact on determining the prognosis of patients with Non-Ischemic Dilated Cardiomyopathy (NICMP).

Objectives: This study aimed to investigate the echocardiographic determinants of RV systolic dysfunction in patients with NICMP.

Patients and Methods: This cross-sectional study was conducted on 79 patients with angiographically normal coronary arteries (mean age: 50.5 ± 12, mean Ejection Fraction (EF): 31 ± 4%) selected through purposive sampling The patients were divided into two groups based on their RV systolic function determined by tissue Doppler systolic velocities (RV-Sm): group A (RV-Sm ≥ 10 cm/s, N = 48) and group B (RV-Sm < 10 cm/s, N = 31). The two groups were compared regarding clinical, demographic, and echocardiographic variables using independent t-test and chi-square test.

Results: The patients with RV systolic dysfunction were found to have higher Brain Natriuretic Peptide (BNP) values (P = 0.006) and worse functional status (New York Heart Association (NYHA) III-IV, P = 0.04) compared to group A. Besides, univariate analysis of the echocardiographic parameters revealed that the patients in group B had significantly (all P values < 0.05) higher Left Atrial Volume Index (LAVI), higher degree of left ventricular diastolic dysfunction (represented by LV-E/Em), higher degree of Functional Mitral Regurgitation (FMR), higher estimated Pulmonary Artery Systolic Pressure (PASP), and higher degree of RV diastolic dysfunction (represented by RV-E/Em) Moreover, multivariate logistic regression analysis showed that severe FMR (P = 0.006) and RV-E/Em (P = 0.016) predicted RV systolic dysfunction independently.

Conclusions: Advanced FMR and worse RV diastolic functions emerged as the independent predictors of RV systolic dysfunction in NICMP correlating to functional status and BNP levels.


The full text is available in PDF.


  • 1.

    The references are available in PDF.

  • © 2016, Shiraz University of Medical Sciences.