Comparison of Renal Function in Coronary Artery Bypass Graft Surgery with Pulsatile versus Non-pulsatile Perfusion: A Randomized Clinical Trial

AUTHORS

Shahriar Mali ORCID 1 , Hossein Montazerghaem ORCID 2 , Sahra Salehi ORCID 1 , * , Sara Jambarsang ORCID 3 , Ahmad Tajamolian ORCID 1

1 Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran

2 Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran

3 Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran

How to Cite: Mali S , Montazerghaem H , Salehi S, Jambarsang S , Tajamolian A . Comparison of Renal Function in Coronary Artery Bypass Graft Surgery with Pulsatile versus Non-pulsatile Perfusion: A Randomized Clinical Trial. Int Cardio Res J. 2030;In Press(In Press):e112221.

ARTICLE INFORMATION

International Cardiovascular Research Journal: In Press (In Press); e112221
Published Online: September 15, 2021
Article Type: Research Article
Received: December 15, 2020
Revised: August 14, 2021
Accepted: August 31, 2021
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Abstract

Background: Despite numerous studies on tissue perfusion, capillary circulation, and
their related factors, there is still no consensus on the utilization of pulsatile versus
non-pulsatile perfusion methods to provide proper perfusion in patients undergoing
Coronary Artery Bypass Graft (CABG) surgery.
Objectives: This study aimed to compare the effects of pulsatile versus non-pulsatile
perfusion methods on renal function in patients undergoing CABG surgery in Shahid
Mohammadi hospital, Bandar Abbas, Iran in 2018.
Methods: In this randomized clinical trial, 50 patients aged > 18 years who underwent
CABG surgery were randomly divided into a pulsatile and a non-pulsatile group (n = 25
in each group). The two groups were compared in terms of laboratory findings including
the plasma levels potassium, sodium, creatinine, and blood urea nitrogen, Glomerular
Filtration Rate (GFR), urinary output, and ejection fraction.
Results: The results revealed a significant difference between the two groups regarding
the trend of GFR changes during the study (P = 0.01). Accordingly, postoperative
GFR increased more in the pulsatile group than in the non-pulsatile group. Moreover,
creatinine and blood urea nitrogen levels reduced in the pulsatile group compared to
the baseline. However, no significant differences were observed in the mean levels of
potassium, sodium, and creatinine, urinary output, and ejection fraction in the two
groups before and after the surgery.
Conclusions: According to the results, pulsatile method was preferred to the nonpulsatile
perfusion method due to its positive effects on creatinine and blood urea
nitrogen levels as well as on GFR during and after the CABG surgery.

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References

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