QT Dispersion after Thrombolytic Therapy


Saeed Oni Heris 1 , Behzad Rahimi 2 , Gholamreza Farid aalaee 3 , * , Mojgan Hajahmadi 2 , Hojjat Sayyadi 4 , Bahman Naghipour 5

1 Shahid Rajaee Heart Center, Tehran, Iran

2 Cardiology Department, Urmia University of Medical Sciences, Urmia, Iran

3 Emergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran

4 Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Department of Anesthesiology, Madani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

How to Cite: Oni Heris S, Rahimi B , Farid aalaee G , Hajahmadi M , Sayyadi H , et al. QT Dispersion after Thrombolytic Therapy, Int Cardio Res J. 2017 ; 8(4):e11681.


International Cardiovascular Research Journal: 8 (4); e11681
Published Online: December 01, 2014
Article Type: Research Article
Received: April 19, 2017
Accepted: July 16, 2014


Background: QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI).

Objectives: This study aimed to assess the effect of thrombolytic therapy on QTd before and 1 hour and 4 days after beginning of thrombolytic therapy.

Patients and Methods: The patients with chest pain and ST Elevated Myocardial Infarction (STEMI) that underwent thrombolytic therapy were enrolled into this study. Streptokinase was the thrombolytic agent in all the patients. Standard 12-lead (ECG) was evaluated before beginning of thrombolytic therapy (QTd 1) and 1 hour (QTd2) and 4 days (QTd3) after thrombolytic therapy. First, ECG was magnified × 10 for exact calculation of QT and QTd. After all, the variables were compared using one–way analysis of variance (ANOVA). Besides, P ≤ 0.05 was considered as statistically significant.

Results: This study was conducted on 160 patients. The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

Conclusions: : Thrombolytic therapy had no significant effects on QTd. Thus, thrombolytic therapy does not increase the risk of arrhythmia.


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