Serum Adropin Level Correlation with Blood Pressure: A case-control study


Marziye Vase ORCID 1 , Amin Taheri ORCID 2 , * , Mina Hemmati ORCID 3

1 Cardiology Department, Vali-e-Asr Hospital, Birjand University of Medical Sciences, Birjand, IR Iran

2 Emergency Department, 22 Bahman Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

3 Biochemistry Department, School of Medicine, Birjand University of Medical Sciences, Birjand, IR Iran

How to Cite: Vase M, Taheri A, Hemmati M. Serum Adropin Level Correlation with Blood Pressure: A case-control study. Int Cardio Res J. 2030;In Press(In Press):e117243.


International Cardiovascular Research Journal: In Press (In Press); e117243
Published Online: September 15, 2021
Article Type: Research Article
Received: June 19, 2021
Revised: July 28, 2021
Accepted: August 22, 2021


Background: Hypertension is considered a fundamental health issue globally, and
adropin is a vascular endothelial protection factor. The increasing prevalence of
Hypertension (HTN); i.e., 20 - 50%, among adult populations in developed countries
is one of the most common causes of Cardiovascular Diseases (CVDs). HTN is also the
major modifiable risk factor for stroke (both ischemic and hemorrhagic). Adropin has
the potential to protect the endothelium by increasing the expression of Nitric Oxide
(NO) synthesis in the endothelium. Nonetheless, few studies have been conducted on the
role of adropin in regulating blood pressure.
Objectives: The present study aimed to assess the adropin level and its relationship with
blood pressure.
Methods: The present observational, case-control study was conducted on 40 hypertensive
and 40 non-hypertensive patients. The patients’ data such as gender, age, years passed
since HTN diagnosis, and blood pressure were recorded by the researcher. Then, adropin
was measured by the Enzyme-Linked Immunosorbent Assay (ELISA) technique. After
all, the significance of the relationship between the variables was statistically analyzed.
Results: The mean level of adropin was 5.44 ± 1.31 pg/mL in the study population. This
measure was 4.91 pg/mL in the case group and 5.98 pg/mL in the control group, and the
difference was statistically significant (P < 0.01). The results of ANCOVA showed that
mean level of adropin was 1.19 units (24.5%) lower in the case group than in the control
group after adjusting for age. The results also revealed a significant difference in the mean
adropin level of the hypertensive patients based on the years passed since diagnosis (P
< 0.01). Moreover, a negative correlation was observed between the adropin level and
systolic blood pressure (rs = -0.273, n = 80, P = 0.014) and diastolic blood pressure (rs =
-0.273, n = 80, P = 0.008). However, no significant correlation was found between age and
adropin level (rs = -0.173, n = 80, P = 0.124).
Conclusions: Hypertensive patients had lower adropin levels in comparison to nonhypertensive
ones. In addition, increase in the number of years passed since diagnosis
was associated with decreased adropin levels.


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