Predictive Value of Cardiovascular Risk Factors for Risk Assessment in Cohort of Shiraz Heart Study


M Fathzadeh 1 , * , Mohammad Javad Zibaeenezhad 2 , MA Babaee Bigi 1 , Shahdad Khosropanah 1 , Mahmood Zamirian 3 , Kamran Aghasadeghi 1 , Alireza Moaref 1 , Firoozeh Abtahi 4 , Seyed Taghi Heydari 1 , Mohammad Hassan Eftekhari 1


2 Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, Iran

3 Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4 cardiology, cardiovascular research center, shiraz university of medical sciences, shiraz, Iran

How to Cite: Fathzadeh M , Zibaeenezhad M J , Babaee Bigi M , Khosropanah S, Zamirian M, et al. Predictive Value of Cardiovascular Risk Factors for Risk Assessment in Cohort of Shiraz Heart Study, Int Cardio Res J. 2010 ; 4(1):e67646.


International Cardiovascular Research Journal: 4 (1); e67646
Published Online: March 30, 2010
Article Type: Research Article
Received: February 19, 2010
Accepted: March 31, 2010


Background: Risk assessment for fast growing burden of cardiovascular diseases is very important and difficult.
As a response to this challenge, in particular, genetic risk factors which potentially modify risk, we conducted
a survey of primary data registry of Shiraz Heart Study on integration and application of family history
data in prevention of cardiovascular disorders.
Method: This study is a longitudinal cohort project to be extended from subpopulations of different job groups
to the community.
Results: Parental family history of MI, diabetes mellitus (DM), hyperlipidemia (HPL), hypertension (HTN) was
reported more frequently among females than males. Histories of MI, DM, HPL, and HTN in both parents were
respectively positive in 2.6%, 2%, 4.6%, and 7.9 % of the participants. Odd ratios (OR) for risk of MI from family
history of MI were 2.7; risk of DM from family history of DM 4.5; risk of HPL from family history of HPL
2.04; and risk of HTN from family history HTN 4.7. Also, family history of MI modifies risk of HPL (OR=1.7,
P<0.0001); and family history of DM modifies risk of HPL (OR=2.04, P<0.0001).
Conclusion: Our primary result shows potent application of family history data in risk assessment of cardiovascular
outcome. In particular, HTN appears as a silent and leading risk modifier. In regard to the course of
continuing Shiraz Heart Study integration of family history of risk factors crucial in public health we suggest to
adopt a network of electronic health records from the “Health House” to the “Heart House”.


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