Kawasaki disease is an acute vasculitis of childhood that predominantly affects the coronary arteries. The etiology of Kawasaki disease remains unknown, although an infectious agent is strongly suspected based on clinical and epidemiologic features. A genetic predisposition is also likely, based on varying incidences among ethnic groups, with higher rates in Asians. Symptoms include fever, conjunctival injection, erythema of the lips and oral mucosa, rash, and cervical lymphadenopathy. Some children with Kawasaki disease develop coronary artery aneurysms or ectasia, ischemic heart disease, or sudden death. Kawasaki disease is the leading cause of acquired heart disease among children in developed countries. This article provides a summary of the history, etiology, clinical diagnosis, treatment guidelines and lifelong follow up of KD.

"/> Kawasaki disease is an acute vasculitis of childhood that predominantly affects the coronary arteries. The etiology of Kawasaki disease remains unknown, although an infectious agent is strongly suspected based on clinical and epidemiologic features. A genetic predisposition is also likely, based on varying incidences among ethnic groups, with higher rates in Asians. Symptoms include fever, conjunctival injection, erythema of the lips and oral mucosa, rash, and cervical lymphadenopathy. Some children with Kawasaki disease develop coronary artery aneurysms or ectasia, ischemic heart disease, or sudden death. Kawasaki disease is the leading cause of acquired heart disease among children in developed countries. This article provides a summary of the history, etiology, clinical diagnosis, treatment guidelines and lifelong follow up of KD.

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Kawasaki Disease

AUTHORS

Ahmad Siadati 1 , * , Farah Sabouni 2 , Parisa Saleh Anaraki 2 , 3

1 Department of Pediatrics, Tehran University of Medical Sciences and Health Services, [email protected], IRAN

2 Department of Pediatrics, Tehran University of Medical Sciences and Health Services, IRAN

3

How to Cite: Siadati A, Sabouni F, Saleh Anaraki P, . Kawasaki Disease, J Compr Ped. Online ahead of Print ; 1(1):9-23.

ARTICLE INFORMATION

Journal of Comprehensive Pediatrics: 1 (1); 9-23
Article Type: Review Article
Received: January 1, 2007
Accepted: January 1, 2007
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Abstract

Kawasaki disease is an acute vasculitis of childhood that predominantly affects the coronary arteries. The etiology of Kawasaki disease remains unknown, although an infectious agent is strongly suspected based on clinical and epidemiologic features. A genetic predisposition is also likely, based on varying incidences among ethnic groups, with higher rates in Asians. Symptoms include fever, conjunctival injection, erythema of the lips and oral mucosa, rash, and cervical lymphadenopathy. Some children with Kawasaki disease develop coronary artery aneurysms or ectasia, ischemic heart disease, or sudden death. Kawasaki disease is the leading cause of acquired heart disease among children in developed countries. This article provides a summary of the history, etiology, clinical diagnosis, treatment guidelines and lifelong follow up of KD.

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