Formulation of griseofulvin topical gel 0.2% using carbomer 940 and HPMC


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How to Cite: Formulation of griseofulvin topical gel 0.2% using carbomer 940 and HPMC, Jentashapir J Cell Mol Biol. Online ahead of Print ; 3(2):322-329.


Jentashapir Journal of Health Research: 3 (2); 322-329
Published Online: June 30, 2012
Article Type: Research Article
Received: December 10, 2011
Accepted: April 27, 2012


Background: The goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability.

Material and methods: To select the best formulation, formulations with different concentration of carbomer and HPMC were evaluated for their appearance. Then evaluated for physicochemical characteristics such as rheologic behavior, viscosity, stability and drug release.

Results: The result showed that the topical gel of griseofulvin prepared with Carbomer 0.5% and HPMC2.5% had good chemical stability, viscosity and drug release. The evaluation of the kinetic of drug release indicated that the formulations containing Carbomer 0.5% and HPMC 2.5% followed zero order release and liner Wagner, respectively. Rheologic data showed that while HPMC gel shows a very mild plastic behavior, Carbomer based gels behave very significantly as a thixotrop pseudo plastic gel.

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© 2012, Jentashapir Journal of Cellular and Molecular Biology. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.