Evaluation of Epidemic Prevention Abilities for Severe Acute Respiratory Syndrome Coronavirus-2 and Middle East Respiratory Syndrome Coronavirus in South Korea


Umar Saeed 1 , * , Zahra Zahid Piracha 1 , Sara Rizwan Uppal 1 , Rizwan Uppal 1

1 Islamabad Diagnostic Center, Islamabad, Pakistan

How to Cite: Saeed U, Zahid Piracha Z, Rizwan Uppal S, Uppal R. Evaluation of Epidemic Prevention Abilities for Severe Acute Respiratory Syndrome Coronavirus-2 and Middle East Respiratory Syndrome Coronavirus in South Korea. Jundishapur J Microbiol. 2021;14(6):e114374. doi: 10.5812/jjm.114374.


Jundishapur Journal of Microbiology: 14 (6); e114374
Published Online: September 6, 2021
Article Type: Brief Report
Received: March 17, 2021
Revised: July 9, 2021
Accepted: July 10, 2021


Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) preferentially infects respiratory tract cells, but it has organotropism. Middle East respiratory syndrome coronavirus (MERS-CoV) is significantly distinct from common cold and SARS coronavirus. In past few years, the SARS-CoV-2 and MERS-CoV caused several deaths in South Korea.

The aim of current study was to assess SARS-CoV-2 and MERS-CoV awareness and epidemic prevention ability in South Koreans.According to our results, out of 1500 participants, 98.8% and 64.3% were aware of SARS-CoV-2 and MERS-CoV, respectively. Moreover, 97% of the participants used masks for prevention of airborne diseases, while 65.3% of the participants reused the same mask for several days. In addition, 50% of the participants were not satisfied with the government support. Future viral epidemics can be prevented by disseminating advanced knowledge and awareness among general public.

1. Background

Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has seriously affected the whole world, South Korea successfully managed to limit the SARS-CoV-2 spread via various strategies. There was no report of full lockdown during the viral spread in the country. People vigilantly responded to the viral epidemics, and based upon experience of previous Middle East respiratory syndrome coronavirus (MERS-CoV) epidemics in South Korea, medical professionals, students, and political leaders actively participated to combat coronavirus disease 2019 (COVID-19). South Koreans used latest technology and digital approaches to introduce smart trace mechanism against COVID-19 patients to tackle the situation tactically. However, there is a need to identify the level of awareness among general populations of South Korea. The current study aimed to evaluate awareness, knowledge, and epidemic prevention abilities among South Koreans between Dec 2019 and Aug 2020.

2. Methods

Viral pathogens are increasing worldwide, and it is anticipated that soon viruses would emerge as highly dangerous entities (1). Prevention is better than cure. Identification of epidemiological patterns of viral spread and dissemination of knowledge and awareness related to risk factors associated with viral transmission in different populations at risk could prevent the emergence of epidemics (2, 3). The SARS-CoV-2 emerged as an epidemic in Asia and became pandemic in early 2020 causing serious public health concern internationally. The MERS-CoV, member of the beta group of coronaviruses, is significantly distinct from SARS coronavirus and common cold coronavirus (4). Some salient features of SARS-CoV-2, SARS-CoV, MERS-CoV, and common cold are shown in Table 1.

The primary source of MERS infecting humans is camels, while bats are considered ultimate reservoir (5). The global number of SARS-CoV-2 positive cases on 31st May 2021was 184 million, and the number is still climbing vigorously. Also, the number of deaths due to COVID-19 was 3.98 million, and the worst affected countries were the United States of America and India (6-8). In 2012, the MERS was initially reported from Kingdom of Saudi Arabia, but later the viral infection was reported from more the 21 different countries, which depicted huge viral spread. During 2014 and 2015, the MERS epidemic in Saudi Arabia infected 688 with 282 deaths, while in South Korea, it infected 186 with 36 deaths. SARS-CoV-2 and MERS have become a major threat to the global health.

Table 1. Silent Features of SARS-CoV-2, SARS-CoV, MERS-CoV and Common Cold
Prognosis SARS-CoV-2SARS-CoVMERS-CoVCommon Cold
Incubation time 2 weeks (approx)1 week (approx)1 week (approx)1 - 4 days (approx)
Symptoms Fever, Cough, Shortness of Breath,Fever, chills, muscle aches, headacheCough Shortness of BreathCough, Sneezing, Runny or Stuffy Nose
Case fatality rate 3.4% (approx)9.6 - 11% (approx)34.4% (approx)0.1% (approx)
Community attack rate 30 - 40% (approx)10 - 60% (approx)4 - 13% (approx)10 - 20% (approx)
Globally infected people 168 million (ongoing pandemic)8098 (in 2003)25001 billion (approx)

The prevalence of viral infections is unfortunately increasing day by day due to the limited awareness among general population (9-12). Poor diagnostic abilities and inadequate knowledge about viral transmission via fomites limit accurate acquisition of prevalence rates (13, 14). Similarly, overcoming COVID-19 vaccine hesitancy and determining adequate antibody levels against SARS-CoV-2 spike protein is a challenging task (15, 16). Although the time of MERS-CoV and SARS-CoV-2 outbreak was different, based upon the experiences of emergency preparedness centers, paramedical staff, and government officials, the surge of COVID-19 in South Korea was effectively tackled within short period of time. Therefore, we asked whether the previous knowledge, awareness, and attitude of general population of South Korea about MERS-CoV contributed to emergency preparedness and development of smart information technologies against SARS-CoV-2 spread. Accordingly, the aim of the study was to assess the knowledge about SARS-CoV-2 and MERS-CoV awareness and prevention in general population of South Korea.

A cross-sectional survey was conducted in multiple cities of South Korea, including Jeonju, Suwon, and Seoul, with a sample size of 1500 from December 2019 to August 2020. Also, 71.4% of the participants were female, 57.1% had a university degree, 21.4% either enrolled or completed their postgraduate studies, and 21.5% were high school graduates. Majority of the participants (40%) were > 40 years of age, 32% were between 20 - 40 years of age, while 28% were below 20 years of age. Moreover, 98.8% of the participants were aware of COVID-19 causing virus SARS-CoV-2, while 64.3% of participants were aware of MERS and associated deaths. According to our results, 99.5% of participants responded that SARS-CoV-2 can be prevented by maintaining safe distance of about two meters, while 78.6% of participants knew that MERS-CoV can be transmitted by air. In addition, 99.5% of participants were aware that SARS-CoV-2 can be transmitted through close contact and droplets, while 21.4% of participants thought that MERS-CoV can be transmitted by close contact. Furthermore, 85% and 13.6% of participants considered that SARS-CoV-2 and MERS-CoV are preventable using vaccines, respectively (Table 2). It should also be mentioned that 97% of the participants used masks for prevention of airborne diseases.

Table 2. Knowledge, Awareness, and Attitudes for Prevention of Study Participants
Knowledge and AttitudeMode of Transmission SARS-CoV-2/MERS-CoVPreventable by Vaccine
SARS-CoV-2 cause COVID-19 (98.8%); MERS-CoV cause MERS (98.8%); SARS-CoV-2 is lethal (60.3%); MERS-CoV is lethal (64.3%)Airborne (78.6%); Droplets (99.5%); Close contact (99.5%/21.4%); Human to human (71.4%); Human to animals (14.3%); Feces (7.1%)SARS-CoV-2 (85%); MERS-CoV (13.6%)

3. Results

In this study, 65.3% of the participants reused the same mask for several days, 99% responded that strictly using masks can prevent SARS-CoV-2 spread, and 31.84% were aware of the fact that the MERS-CoV spread can be prevented by using mask in crowded areas and by maintaining good personal hygiene through washing hands frequently. Moreover, 81% of the participants believed that bats are the source of SARS-CoV-2 while 71.4% responded that the source of MERS-CoV spread was camels (Table 3). Also, 93% and 71.4% of participants thought that SARS-CoV-2 and MERS-CoV can be transmitted through human-to-human route, respectively. In addition, 14.3% of participants considered that SARS-CoV-2 and MERS-CoV can be transmitted from humans to animals, and 7.1% considered that SARS-CoV-2 or MERS-CoV can be transmitted by feces (Table 2). Data analysis revealed that 21.4% of the participants were highly satisfied with the support provided by Korean government to combat SARS-CoV-2 and MERS outbreak (Table 3), 28.6% were satisfied up to some extent, while 35.7% were not satisfied with the efforts made by government.

Table 3. Utilization of SOPs and Level of Satisfaction with Government Efforts
Utilization of SOPsSource of VirusEfforts by Government
Usage of Masks (97%); Re-usage of Masks (65.3%); Masks usage is critical for SARS-CoV-2 (99%); Masks usage is critical for; MERS-CoV (31.84%)Bats source of SARS-CoV-2 (81%); Camels source of MERS-CoV (71.4%)Highly satisfied (21.4%); Satisfied to some extent (28.6%); Not satisfied (35.7%)

4. Conclusions

Efforts are still needed to improve knowledge and awareness level about prevention of viral diseases among general population in South Korea. Policy makers should not only provide wider opportunities for the dissemination of knowledge and awareness about viral transmission, but also focus on epidemiological patterns of emerging epidemics in world. In educational institutes and offices, disseminating online awareness programs and conducting online seminars related to biosafety and virus control could be a better strategy to prevent future viral epidemics.



  • 1.

    Saeed U, Mazoor S, Jalal N, Zahid Piracha Z. Contemplating the importance of toll-like receptors I and II regarding human viral pathogenesis. Jundishapur J Microbiol. 2015;8(1). e13348. doi: 10.5812/jjm.13348. [PubMed: 25763131]. [PubMed Central: PMC4344769].

  • 2.

    Saeed U, Waheed Y, Manzoor S, Ashraf M. Identification of novel silent HIV propagation routes in Pakistan. World J Virol. 2013;2(3):136-8. doi: 10.5501/wjv.v2.i3.136. [PubMed: 24255884]. [PubMed Central: PMC3832857].

  • 3.

    Saeed U, Manzoor S. Risk factors associated with transmission of hepatitis B and hepatitis C virus in Pakistan. Glob J Med Res. 2014;14(1):14-9.

  • 4.

    WHO. Middle East respiratory syndrome coronavirus (MERS-CoV). World Health Organization; 2016. Available from: http://www.who.int/mediacentre/factsheets/mers-cov/en/.

  • 5.

    Wikipedia. Middle East respiratory syndrome coronavirus (MERS‐CoV). 2016. Available from: https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome_coronavirus.

  • 6.

    Worldometers. COVID-19 update. 2021. Available from: www.worldometers.info/coronavirus.

  • 7.

    Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177-9. doi: 10.1056/NEJMc2001737. [PubMed: 32074444]. [PubMed Central: PMC7121626].

  • 8.

    Puelles VG, Lutgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, et al. Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med. 2020;383(6):590-2. doi: 10.1056/NEJMc2011400. [PubMed: 32402155]. [PubMed Central: PMC7240771].

  • 9.

    Saeed U, Waheed Y, Ashraf M. Hepatitis B and hepatitis C viruses: a review of viral genomes, viral induced host immune responses, genotypic distributions and worldwide epidemiology. Asian Pac J Trop Dis. 2014;4(2):88-96. doi: 10.1016/s2222-1808(14)60322-4.

  • 10.

    Saeed U, Waheed Y, Ashraf M, Waheed U, Anjum S, Afzal MS. Estimation of hepatitis B virus, hepatitis C virus, and different clinical parameters in the thalassemic population of capital twin cities of Pakistan. Virology (Auckl). 2015;6:11-6. doi: 10.4137/VRT.S31744. [PubMed: 26568681]. [PubMed Central: PMC4636113].

  • 11.

    Saeed U, Uppal SR, Piracha ZZ, Rasheed A, Aftab Z, Zaheer H, et al. Evaluation of SARS-CoV-2 antigen-based rapid diagnostic kits in Pakistan: formulation of COVID-19 national testing strategy. Virol J. 2021;18(1):34. doi: 10.1186/s12985-021-01505-3. [PubMed: 33581714]. [PubMed Central: PMC7881305].

  • 12.

    Saeed U, Rizwan Uppal S, Zahid Piracha Z, Uppal R. Azithromycin treatment for SARS-CoV-2-related COVID-19 pandemic could worsen extensively drug resistant (XDR) typhoid: A risk of losing the last bullet against Salmonella enterica serovar typhi. Jundishapur J Microbiol. 2021;14(1). e113874. doi: 10.5812/jjm.113874.

  • 13.

    Saeed U, Uppal SR, Piracha ZZ, Uppal R. COVID-19 transmission via fomites at low temperature: A potential silent SARS-CoV-2 propagation route. Am J Biomed Sci & Res. 2021;12(1):80-2.

  • 14.

    Saeed U, Uppal SR, Piracha ZZ, Khan AA, Rasheed A, Zaheer H, et al. Effectivity analysis of SARS-CoV-2 nasopharyngeal swab rapid testing kits in Pakistan: A scenario of inadequate COVID-19 diagnosis. Res Sq. 2021. doi: 10.21203/rs.3.rs-315851/v1.

  • 15.

    Saeed U, Uppal SR, Piracha ZZ, Uppal R. SARS-CoV-2 Spike Antibody Levels Trend among Sinopharm Vaccinated People. Iran J Public Health. 2021;50(7):1486-7. doi: 10.18502/ijph.v50i7.6640.

  • 16.

    Saeed U, Uppal SR, Piracha ZZ, Khan AA, Rasheed A, Waheed A, et al. Evaluation of SARS-CoV-2 spike antibody levels among Sputnik V first dose vaccinated people in Pakistan: formulation of national anti-COVID-19 mass vaccination strategy. Res Sq. 2021. doi: 10.21203/rs.3.rs-480406/v1.

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