Radioprotective Effects of Allium Jesdianum Extract on Reduction of Pancrease Damages Following γ-radiation Through Down-regulation of Apoptotic genes, Antioxidants Regulation, and Inflammatory Markers Suppression

AUTHORS

Shiva Roshankhah ORCID 1 , Saleh Salehi Zahabi 2 , Mohammad Reza Gholami 1 , Amir Abdolmaleki 1 , Mohammad Reza Salahshoor ORCID 1 , *

1 Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Radiology and Nuclear Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Roshankhah S , Salehi Zahabi S, Gholami M R , Abdolmaleki A , Salahshoor M R. Radioprotective Effects of Allium Jesdianum Extract on Reduction of Pancrease Damages Following γ-radiation Through Down-regulation of Apoptotic genes, Antioxidants Regulation, and Inflammatory Markers Suppression, Jundishapur J Nat Pharm Prod.2021 In Press(In Press): e103997.

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: In Press (In Press); e103997
Published Online: May 30, 2021
Article Type: Research Article
Received: April 21, 2020
Revised: December 24, 2020
Accepted: January 06, 2021
Accepted Article scheduled for 16 (3)
READ FULL TEXT

Abstract

Background: Allium Jesdianum (AJ), as a plant in onion category, has antioxidant features. γ-ray potentially generates oxidative stress in living organisms.

Objectives: In this study, the probable therapeutics effects of AJ on destruction of pancreas tissue following γ-ray were evaluated.

Methods: Sixty-four mature NMRI mice (8 animals in each group) were assigned in 8 groups as order; 1: control, 2:γ-ray (dose rate of 1Gy/min), 3-5: AJ extract (500, 1000, and 2000 mg/kg), and 6-8: AJ + γ-ray. AJ Extract was prepared, and all administrations were applied orally for 70 consecutive days. Antioxidant parameters (nitrite oxide, peroxidation, and ferric reducing ability of plasma (FRAP)), apoptotic genes expression (p53 and Bax, by real-time quantitative PCR), and blood concentrations of glucose and insulin were determined biochemically and genetically. Inflammatory cytokines were evaluated by the ELISA technique. The number and diameter of Langerhan islets were also studied histologically.

Results: γ-ray increased the levels of all parameters significantly (except FRAP, insulin and morphometric parameters, which were reduced) in γ-ray group compared to the control group (P < 0.05). In γ-ray and AJ + γ-ray groups, all factors were reduced significantly (except FRAP, insulin and morphometric parameters, which were increased) compared to the γ-ray group (P < 0.05).

Conclusions: Administration of AJ extract could decrease the damage and radiosensitization in pancreatic cells induced by γ-ray.

Fulltext

© 2021, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
COMMENTS

LEAVE A COMMENT HERE: