The ethanol extract of Bougainvillea spectabilis (ALBS) leaves were studied for its antiulcer activity against aspirin plus pylorus ligation induced gastric ulcer, HCl /ethanol induced ulcer and water immersion stress induced ulcer in rats. The results were compared with ranitidine, sucralfate, omeprazole respectively, for each model suggesting a mechanism for the pharmacological action (antisecretory, cytoprotection, proton pump hypothesis were evaluated). The ethanol extract of Bougainvillea spectabilis showed reduction in gastric volume, free acidity, total acidity and the ulcer inhibition was found to be 100%. The plant extract showed significant cytoprotective effect 89.71% and the extract showed protection index 72% in water immersion stress induced ulcer.

"/> The ethanol extract of Bougainvillea spectabilis (ALBS) leaves were studied for its antiulcer activity against aspirin plus pylorus ligation induced gastric ulcer, HCl /ethanol induced ulcer and water immersion stress induced ulcer in rats. The results were compared with ranitidine, sucralfate, omeprazole respectively, for each model suggesting a mechanism for the pharmacological action (antisecretory, cytoprotection, proton pump hypothesis were evaluated). The ethanol extract of Bougainvillea spectabilis showed reduction in gastric volume, free acidity, total acidity and the ulcer inhibition was found to be 100%. The plant extract showed significant cytoprotective effect 89.71% and the extract showed protection index 72% in water immersion stress induced ulcer.

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ANTIULCER ACTIVITY OF CRUDE ALCOHOLIC EXTRACTS OF BOUGAINVILLEA SPECTABILIS WILLD

AUTHORS

P Malairajan 1 , * , G Gopalakrishnan 2 , S Narasimhan 3 , K Kala Veni Jessi 4

1 1ROFEL Shri G.M Bilakhia College of Pharmacy, Vapi(West) -396 191, Valsad District, [email protected], Gujarat State, India

2 Singapore 638 403

3 Director, Asthagiri Herbal Research foundation, Tambaram Sanatorium, Chennai-600053 Tamilnadu, India

4 India

How to Cite: Malairajan P, Gopalakrishnan G, Narasimhan S, Jessi K. ANTIULCER ACTIVITY OF CRUDE ALCOHOLIC EXTRACTS OF BOUGAINVILLEA SPECTABILIS WILLD, Jundishapur J Nat Pharm Prod. Online ahead of Print ; 2(1):1-6.

ARTICLE INFORMATION

Jundishapur Journal of Natural Pharmaceutical Products: 2 (1); 1-6
Article Type: Research Article
Received: February 14, 2006
Accepted: April 14, 2007
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Abstract

The ethanol extract of Bougainvillea spectabilis (ALBS) leaves were studied for its antiulcer activity against aspirin plus pylorus ligation induced gastric ulcer, HCl /ethanol induced ulcer and water immersion stress induced ulcer in rats. The results were compared with ranitidine, sucralfate, omeprazole respectively, for each model suggesting a mechanism for the pharmacological action (antisecretory, cytoprotection, proton pump hypothesis were evaluated). The ethanol extract of Bougainvillea spectabilis showed reduction in gastric volume, free acidity, total acidity and the ulcer inhibition was found to be 100%. The plant extract showed significant cytoprotective effect 89.71% and the extract showed protection index 72% in water immersion stress induced ulcer.

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