Effect of prophylactic gabapentin on post operative nausea and vomiting after laparoscopic cholecystectomy: a randomized controlled trial

AUTHORS

Ahmadreza Soroush 1 , Hosein Masoomi 1 , Zhamak Khorgami 1 , * , Seyed Mojtaba Marashi 2 , Roza Mofid 1

1 Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, [email protected], Iran

2 Department of Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Iran

How to Cite: Soroush A, Masoomi H, Khorgami Z, Marashi S, Mofid R. Effect of prophylactic gabapentin on post operative nausea and vomiting after laparoscopic cholecystectomy: a randomized controlled trial, J Minim Invasive Surg Sci. Online ahead of Print ; 1(1):17-20. doi: 10.5812/jmiss.3298.

ARTICLE INFORMATION

Journal of Minimally Invasive Surgical Sciences: 1 (1); 17-20
Published Online: June 30, 2012
Article Type: Research Article
Received: October 29, 2011
Accepted: December 21, 2011
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Abstract

Background: Postoperative nausea and vomiting (PONV) is a frequent and unpleasant adverse event associated with surgery. The reported incidence of PONV after laparoscopic cholecystectomy (LC) is quite high. Despite the use of di?erent drugs to prevent or relieve PONV, it continues to be undermanaged. Recently, studies have been undertaken to determine if gabapentin can be useful for the prevention of PONV. \r\nObjectives: We assessed the e?ect of perioperative gabapentin administration on PONV after LC. \r\nPatients and Methods: We enrolled 92 patients scheduled to undergo LC for a randomized double-blind placebo-controlled study. Patients were divided into two groups of 46 patients. The intervention group received two doses of 600 mg gabapentin: one dose two hours before surgery and one dose six hours after surgery. Similarly Control group received capsules in the same size and shape as gabapentin capsules. All Patients were observed for PONV and adverse e?ects of the drug for 24 h. Metoclopramid (10 mg) was used as the antiemetic in patients with severe PONV in necessary circumstances. Total metoclopramid consumption were recorded. \r\nResults: There were no demographic differences between the 2 study groups. Within 24 h of LC, 12 patients who received gabapentin (26.1%) and 30 patients who received a placebo (65.2%) experienced nausea (P < 0.001), while 10 patients in the intervention group (21.7%) and 24 patients in the control group (52.3%) vomited (P = 0.002). Metoclopramid was used to control PONV in 11 intervention patients (23.9%) and 29 control patients (63%; P = 0.001). \r\nConclusions: Perioperative administration of gabapentin signi?cantly decreases the incidence of PONV and the requirement for postoperative antiemetic treatment following LC.

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© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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