Erectile Dysfunction and Infertility: A Pilot Study in Male Partners of Infertile Couples


Son Trinh The 1 , Su Hoang Xuan 2 , Ai Hoang Van 1 , Trinh Nguyen Ba 3 , Hoang Le 4 , Trang Quan Van 1 , Minh Pham Duc 1 , Tung Nguyen Thanh 1 , Tuan Ngo Anh 5 , Trang Vu Thi Thu 6 , Quyet Do 5 , Binh Do Nhu 5 , 7 , *

1 Military Institute of Clinical Embryology and Histology, Vietnam Military Medical University, Hanoi, Vietnam

2 Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam

3 In vitro Fertility Center, Central Military Hospital 108, Hanoi, Vietnam

4 In vitro Fertility Center, Tam Anh General Hospital, Hanoi, Vietnam

5 Vietnam Military Medical University, Hanoi, Vietnam

6 Hung Yen Obstetrics and Pediatrics Hospital, Hungyen, Vietnam

7 Military Hospital 103, Hanoi, Vietnam

How to Cite: Trinh The S, Hoang Xuan S, Hoang Van A, Nguyen Ba T, Le H, et al. Erectile Dysfunction and Infertility: A Pilot Study in Male Partners of Infertile Couples, Nephro-Urol Mon.2021 In Press(In Press): e112638.


Nephro-Urology Monthly: In Press (In Press); e112638
Published Online: May 25, 2021
Article Type: Research Article
Received: January 02, 2021
Revised: March 07, 2021
Accepted: March 24, 2021


Background: Erectile dysfunction (ED) along with infertility are important health issues, which affects negatively the quality of life, couple’s relationship and emerging as an early marker for evaluation of decreased general health status

Purpose: This pilot study was to investigate the prevalence and risk factors of erectile dysfunction (ED) in men of infertile couples from an in vitro fertility center in northern Vietnam.

Methods: A total of 138 men of infertility couples were enrolled in this study from January to May 2018. The International Index of Erectile Function questionnaire scale was used to access the severity of ED and several related factors were also collected to determine risk factors. 

Results: The prevalence of ED among men of infertile couples was 18.1%, including 13 mild ED (9.4%), 7 mild to moderate ED (5.1%), 2 moderate ED (1.4%) and 1 severe ED (0.7%). Using logistic regression analysis, we showed that risk factors associated ED were smoking above 5 pack/years with OR = 3.16, CI = 0.98 – 10.18, p = 0.05; not graduating junior high school, OR =  5.11, CI = 1.11 – 23.8, p = 0.03, and azoospermia, OR = 7.55 , CI = 2.18 – 26.16, p = 0.001. We observed relatively high OR in men with smoking under 5 pack/years (OR = 2.51), abnormal semen analysis (hypospermia, oligozoospermia, asthenozoospermia, or teratozoospermia) (OR=2.36), but there was not significant differences compared with reference group.

Conclusion: The prevalence of ED among men of infertile couples in this study was higher than infertile men.  Low level of education, smoking for a long period, and azoospermia were the main risk factors of ED in men. Further large-scale studies are needed to extend the results.


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