Background and Aims: Overweight and obesity are significant risk factors for chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of renal function. We evaluated the accuracy of the Cockroft-Gault, MDRD and modified MDRD formulae in predicting GFR in overweight and obese subjects and also determined the relationship between Body Mass Index (BMI), weight and GFR.

Methods: Healthy volunteers with BMI ≥23kg/m² were recruited and subjected to blood and urine investigations, renal ultrasonography and 99mTc-DTPA renal scan. The correlation, accuracy and precision of the eGFR derived from each formula were compared with reference GFR as determined by 99mTc-DTPA.

Results: A total of 101 subjects with a median weight of 74.0kg (68.0-84.7) and median BMI of 29.6 kg/m² (27.2-33.2) were recruited. Their mean GFR 99mTc-DTPA was 120.3± 24.5ml/mm/1.73m². Although the eGFRs derived from all formulae correlated with GFR 99mTc-DTPA, only those derived from the MDRD and modified MDRD had small biases and better precision in estimating GFR. While GFR significantly correlated with the subjects' weight (p=0.036), it didn't with their BMI (p=0.302).

Conclusions: The MDRD-based formulae were better in estimating GFR in overweight and obese Malaysian subjects. GFR correlated with subjects' weight rather than BMI.

"/> Background and Aims: Overweight and obesity are significant risk factors for chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of renal function. We evaluated the accuracy of the Cockroft-Gault, MDRD and modified MDRD formulae in predicting GFR in overweight and obese subjects and also determined the relationship between Body Mass Index (BMI), weight and GFR.

Methods: Healthy volunteers with BMI ≥23kg/m² were recruited and subjected to blood and urine investigations, renal ultrasonography and 99mTc-DTPA renal scan. The correlation, accuracy and precision of the eGFR derived from each formula were compared with reference GFR as determined by 99mTc-DTPA.

Results: A total of 101 subjects with a median weight of 74.0kg (68.0-84.7) and median BMI of 29.6 kg/m² (27.2-33.2) were recruited. Their mean GFR 99mTc-DTPA was 120.3± 24.5ml/mm/1.73m². Although the eGFRs derived from all formulae correlated with GFR 99mTc-DTPA, only those derived from the MDRD and modified MDRD had small biases and better precision in estimating GFR. While GFR significantly correlated with the subjects' weight (p=0.036), it didn't with their BMI (p=0.302).

Conclusions: The MDRD-based formulae were better in estimating GFR in overweight and obese Malaysian subjects. GFR correlated with subjects' weight rather than BMI.

"/>
ARTICLE AUTHORS
ARTICLE INFO

Estimating Glomerular Filtration Rate in Overweight and Obese Malaysian Subjects

AUTHORS

Nor Hayati Shaharudin 1 , Abdul Halim Abdul Gafor 2 , * , Soehardy Zainudin 1 , Norella CT Kong 1 , Aini Abdul Aziz 1 , Shamsul Azhar Shah 1

1 Nephrology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Lumpur, Malaysia

2 Nephrology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, [email protected], Lumpur, Malaysia

How to Cite: Shaharudin N, Abdul Gafor A, Zainudin S, Kong N, Aziz A, et al. Estimating Glomerular Filtration Rate in Overweight and Obese Malaysian Subjects, Nephro-Urol Mon. Online ahead of Print ; 3(1):15-22.

ARTICLE INFORMATION

Nephro-Urology Monthly: 3 (1); 15-22
Article Type: Research Article
Received: February 23, 2010
Accepted: March 15, 2010
READ FULL TEXT

Abstract

Background and Aims: Overweight and obesity are significant risk factors for chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of renal function. We evaluated the accuracy of the Cockroft-Gault, MDRD and modified MDRD formulae in predicting GFR in overweight and obese subjects and also determined the relationship between Body Mass Index (BMI), weight and GFR.

Methods: Healthy volunteers with BMI ≥23kg/m² were recruited and subjected to blood and urine investigations, renal ultrasonography and 99mTc-DTPA renal scan. The correlation, accuracy and precision of the eGFR derived from each formula were compared with reference GFR as determined by 99mTc-DTPA.

Results: A total of 101 subjects with a median weight of 74.0kg (68.0-84.7) and median BMI of 29.6 kg/m² (27.2-33.2) were recruited. Their mean GFR 99mTc-DTPA was 120.3± 24.5ml/mm/1.73m². Although the eGFRs derived from all formulae correlated with GFR 99mTc-DTPA, only those derived from the MDRD and modified MDRD had small biases and better precision in estimating GFR. While GFR significantly correlated with the subjects' weight (p=0.036), it didn't with their BMI (p=0.302).

Conclusions: The MDRD-based formulae were better in estimating GFR in overweight and obese Malaysian subjects. GFR correlated with subjects' weight rather than BMI.

Full Text

Full text is available in PDF

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
COMMENTS

LEAVE A COMMENT HERE: