Background: Immunosuppression increases the incidence of cancer and promotes the growth of neoplasm in kidney transplant recipients. There have been few reports on the incidence of gastrointestinal (GI) and liver cancers from transplant registries.

Methods: In the current study, we collected data from 8 kidney transplant centers in Iran between 1984 and 2008, to detect the incidence, type, and outcome of GI and liver cancers after kidney transplantation. Only histologically confirmed tumors that occurred after renal transplantation were included in the analysis. We also compared their data with 3028 kidney recipients of two transplant centers.

Results: Of the 9355 patients who underwent kidney transplantation, GI tumors were detected in 14 (0.15%), 12 males and 2 females. Male gender was predominant between patients with GI and liver tumors (P=0.02). Colorectal carcinoma (CRC) was the most common GI cancer (n=7) followed by gastric adenocarcinoma (n=3) and hepatocellular carcinoma (n=3). Mean age of patients was 48.0 ± 10.6 (27 - 61) years and mean time of diagnosis since transplantation was 72 (5-284) months. Significant risk factors for the development of a de novo malignancy were male gender, older age (>50 years of age) and the total time on immunosuppression. Patient and graft survival rates from the time of GI and liver cancers onset were poor.

Conclusions: CRC was the most common GI tumor following kidney transplantation and was predominant in male. GI and liver malignancies have poor prognosis and early diagnosis and prompt treatment of the post- transplant malignancies is essential.

"/> Background: Immunosuppression increases the incidence of cancer and promotes the growth of neoplasm in kidney transplant recipients. There have been few reports on the incidence of gastrointestinal (GI) and liver cancers from transplant registries.

Methods: In the current study, we collected data from 8 kidney transplant centers in Iran between 1984 and 2008, to detect the incidence, type, and outcome of GI and liver cancers after kidney transplantation. Only histologically confirmed tumors that occurred after renal transplantation were included in the analysis. We also compared their data with 3028 kidney recipients of two transplant centers.

Results: Of the 9355 patients who underwent kidney transplantation, GI tumors were detected in 14 (0.15%), 12 males and 2 females. Male gender was predominant between patients with GI and liver tumors (P=0.02). Colorectal carcinoma (CRC) was the most common GI cancer (n=7) followed by gastric adenocarcinoma (n=3) and hepatocellular carcinoma (n=3). Mean age of patients was 48.0 ± 10.6 (27 - 61) years and mean time of diagnosis since transplantation was 72 (5-284) months. Significant risk factors for the development of a de novo malignancy were male gender, older age (>50 years of age) and the total time on immunosuppression. Patient and graft survival rates from the time of GI and liver cancers onset were poor.

Conclusions: CRC was the most common GI tumor following kidney transplantation and was predominant in male. GI and liver malignancies have poor prognosis and early diagnosis and prompt treatment of the post- transplant malignancies is essential.

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ARTICLE AUTHORS
ARTICLE INFO

Gastrointestinal and Liver Malignancies after Renal Transplantation: A Multicenter Study

AUTHORS

Mohsen Nafar 1 , * , Mahboob Lessan Pezeshki 2 , Heshmatollah Shahbazian 2 , Fatemeh Pour-Reza Gholi 2 , Ahmad Firouzan 2 , Pedram Ahmadpour 2 , Khadidheh Makhdomi 3 , Ali Ghafari 3 , Mohammad Reza Ardalan 4 , Jamshid Roozbeh 5 , Mojgan Jalalzadeh 6 , Mohmmad Hassan Ghadiani 2 , Masoud Khosravi 7 , Efat Razeghi 2

1 Department of Nephrology,Shahid Beheshti University of Medical Sciences, [email protected], Iran

2 Department of Nephrology, Tehran University of Medical Sciences, Iran

3 Department of Nephrology, Urmia University of Medical Sciences, Iran

4 Department of Nephrology, Tabriz University of Medical Sciences, Iran

5 Department of Nephrology, Shiraz University of Medical Sciences, Iran

6 Department of Nephrology, Zanjan University of Medical Sciences, Iran

7 Department of Nephrology, Rasht University of Medical Sciences, Iran

How to Cite: Nafar M, Pezeshki M, Shahbazian H, Gholi F, Firouzan A, et al. Gastrointestinal and Liver Malignancies after Renal Transplantation: A Multicenter Study, Nephro-Urol Mon. Online ahead of Print ; 1(1):33-38.

ARTICLE INFORMATION

Nephro-Urology Monthly: 1 (1); 33-38
Article Type: Research Article
Received: March 12, 2009
Accepted: April 8, 2009
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Abstract

Background: Immunosuppression increases the incidence of cancer and promotes the growth of neoplasm in kidney transplant recipients. There have been few reports on the incidence of gastrointestinal (GI) and liver cancers from transplant registries.

Methods: In the current study, we collected data from 8 kidney transplant centers in Iran between 1984 and 2008, to detect the incidence, type, and outcome of GI and liver cancers after kidney transplantation. Only histologically confirmed tumors that occurred after renal transplantation were included in the analysis. We also compared their data with 3028 kidney recipients of two transplant centers.

Results: Of the 9355 patients who underwent kidney transplantation, GI tumors were detected in 14 (0.15%), 12 males and 2 females. Male gender was predominant between patients with GI and liver tumors (P=0.02). Colorectal carcinoma (CRC) was the most common GI cancer (n=7) followed by gastric adenocarcinoma (n=3) and hepatocellular carcinoma (n=3). Mean age of patients was 48.0 ± 10.6 (27 - 61) years and mean time of diagnosis since transplantation was 72 (5-284) months. Significant risk factors for the development of a de novo malignancy were male gender, older age (>50 years of age) and the total time on immunosuppression. Patient and graft survival rates from the time of GI and liver cancers onset were poor.

Conclusions: CRC was the most common GI tumor following kidney transplantation and was predominant in male. GI and liver malignancies have poor prognosis and early diagnosis and prompt treatment of the post- transplant malignancies is essential.

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