Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology with typical clinical features of slowly progressive renal failure in the third decade of life. Histological findings characterize striking enlarged and hyperchromic nuclei in numerous tubular epithelial cells throughout the nephron accompanied by interstitial fibrosis around atrophic tubules. Herein, we report a case of 30 year-old patient who presented with asymptomatic progressive renal dysfunction in 2009. Renal biopsy revealed chronic tubulointerstitial nephritis and an unusually marked karyomegaly particularly of the tubular epithelium.

 


 

Implication for health policy/practice/research/medical education:
This case report describes a rare cause of chronic kidney disease that should be considered when a young patient presented as tubulointerstitial nephritis pattern.
Please cite this paper as:
Uz E, Bayram Y, Haltas H, Bavbek N, Kanbay M, Guz G, et al. Karyomegalic tubulointerstitial nephritis: A rare cause of chronic kidney disease. Nephro-Urol Mon. 2011;3(3):201-203.
Article history:
Received: 13 Oct 2010
Revised: 9 Nov 2010
Accepted: 20 Nov 2010

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Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology with typical clinical features of slowly progressive renal failure in the third decade of life. Histological findings characterize striking enlarged and hyperchromic nuclei in numerous tubular epithelial cells throughout the nephron accompanied by interstitial fibrosis around atrophic tubules. Herein, we report a case of 30 year-old patient who presented with asymptomatic progressive renal dysfunction in 2009. Renal biopsy revealed chronic tubulointerstitial nephritis and an unusually marked karyomegaly particularly of the tubular epithelium.

 


 

Implication for health policy/practice/research/medical education:
This case report describes a rare cause of chronic kidney disease that should be considered when a young patient presented as tubulointerstitial nephritis pattern.
Please cite this paper as:
Uz E, Bayram Y, Haltas H, Bavbek N, Kanbay M, Guz G, et al. Karyomegalic tubulointerstitial nephritis: A rare cause of chronic kidney disease. Nephro-Urol Mon. 2011;3(3):201-203.
Article history:
Received: 13 Oct 2010
Revised: 9 Nov 2010
Accepted: 20 Nov 2010

"/>

Karyomegalic tubulointerstitial nephritis: A rare cause of chronic kidney disease

AUTHORS

Ebru Uz 1 , Yeter Bayram 2 , * , Hacer Haltas 1 , Nuket Bavbek 1 , Mehmet Kanbay 1 , Galip Guz 1 , Ali Akay 1

1 Department of Nephrology, Fatih University Medical School, Turkey

2 Department of Internal Medicine, Fatih University Medical School, [email protected], Turkey

How to Cite: Uz E, Bayram Y, Haltas H, Bavbek N, Kanbay M, et al. Karyomegalic tubulointerstitial nephritis: A rare cause of chronic kidney disease, Nephro-Urol Mon. Online ahead of Print ; 3(3):201-203.

ARTICLE INFORMATION

Nephro-Urology Monthly: 3 (3); 201-203
Article Type: Case Report
Received: October 13, 2010
Accepted: November 20, 2010
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Abstract

Karyomegalic tubulointerstitial nephritis is a rare disease of uncertain etiology with typical clinical features of slowly progressive renal failure in the third decade of life. Histological findings characterize striking enlarged and hyperchromic nuclei in numerous tubular epithelial cells throughout the nephron accompanied by interstitial fibrosis around atrophic tubules. Herein, we report a case of 30 year-old patient who presented with asymptomatic progressive renal dysfunction in 2009. Renal biopsy revealed chronic tubulointerstitial nephritis and an unusually marked karyomegaly particularly of the tubular epithelium.

 


 

Implication for health policy/practice/research/medical education:
This case report describes a rare cause of chronic kidney disease that should be considered when a young patient presented as tubulointerstitial nephritis pattern.
Please cite this paper as:
Uz E, Bayram Y, Haltas H, Bavbek N, Kanbay M, Guz G, et al. Karyomegalic tubulointerstitial nephritis: A rare cause of chronic kidney disease. Nephro-Urol Mon. 2011;3(3):201-203.
Article history:
Received: 13 Oct 2010
Revised: 9 Nov 2010
Accepted: 20 Nov 2010

Full Text

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