Evaluating the Impact of COVID-19 Pandemic on Organ Donation and Transplantation Activities in Iran

AUTHORS

Marzieh Latifi 1 , Farzaneh Bagherpour 1 , Arefeh Jafarian 2 , Amirali Hamidiyeh 2 , 3 , Ehsan Javandoost 4 , Zeinab Mansouri 1 , Maryam Pourhosien 1 , Niloufar Tirgar 2 , Amirmohammad Amirkhani 5 , 6 , Sanaz Dehghani 1 , 2 , *

1 Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Iranian Tissue Bank & Research Center, Gene, Cell & Tissue Research institute, Tehran University of Medical Sciences, Tehran, Iran

3 Professor of Pediatric Hematology/Oncology and Stem Cell Transplantation, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canad

5 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

6 Stem Cell And Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

How to Cite: Latifi M, Bagherpour F, Jafarian A, Hamidiyeh A, Javandoost E, et al. Evaluating the Impact of COVID-19 Pandemic on Organ Donation and Transplantation Activities in Iran. Shiraz E-Med J.In Press(In Press):e116048. doi: 10.5812/semj.116048.

ARTICLE INFORMATION

Shiraz E-Medical Journal: In Press (In Press); e116048
Published Online: September 5, 2021
Article Type: Brief Report
Received: May 9, 2021
Revised: July 4, 2021
Accepted: July 6, 2021
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Abstract

Background: Coronavirus disease 2019 (COVID-19) pandemic has had a great impact on reducing organ transplantation activities.

Objectives: The aim of this study was to determine the donation and transplantation activities before and after COVID-19 outbreak in Iran.

Methods: This retrospective study compared the donation and transplantation activities in two specific 9-month periods (Average period of March - Dec 2018-2019 Vs. March - Dec 2020). The questionnaire included the numbers of brain death confirmations, family consents, organ recoveries, and transplanted solid organs. The questionnaire was sent by email to the chief executive of the organ procurement unit.

Results: A total of 15 organ procurement units responded to the survey. The largest reduction was seen in tissue transplantations (62.5%) during two time intervals. Brain death due to head trauma significantly decreased in two time intervals and suicide increased by 14.44% during the COVID-19 pandemic compared to 2018-2019 period. Significant reductions between the median of donation (P = 0.0187), median of potential donor (P = 0.005), median of family consent (P = 0.002), and median of eligible donor (P = 0.009) were observed during the two time periods.

Conclusions: A significant reduction was observed in organ donation and transplantation during COVID-19 pandemic. Developing protocols and establishing new strategies for evaluation of organ donation to ensure the safety of organ recipients and medical staff is necessary.

1. Background

There have been several emerging viral diseases since 1980s. Currently, coronavirus disease 2019 (COVID-19) caused by SARS‐CoV‐2 has spread throughout the world (1).

In December 2019, a new coronavirus appeared in Wuhan, China. Then, the number of patients increased, and it spread rapidly in almost all countries in the world (2, 3). SARS-CoV-2 is the cause of the severe acute respiratory syndrome epidemic known as COVID 2019 (4). On March 11, 2020, the World Health Organization (WHO) announced the disease as a ‘global pandemic’ (5).

COVID-19 pandemic has had a great impact on reducing organ donation and transplantation activities (6). The risk of transmission of COVID-19 from a donor is unknown (7). Recent guidelines recommend that all potential donors be tested for SARS-CoV-2, and positive donors must be suspended. Asymptomatic individuals who are in contact with COVID-19 patients are removed from the donation list (2).

The incidence rate and impact of COVID-19 have been reported to be very different. Some countries have reported the rate of donation to be reduced to less than 50% during the pandemic (8).

In the UK, compared with 2019, the number of brain death donors decreased by 66% and the number of transplants decreased by 68% (6). However, COVID-19 has had no significant effect on the number of deceased organ donors in Hong Kong (9), Slovenia, and Germany (10).

On February 19, Iran confirmed two cases of death due to COVID-19, which rapidly spread throughout the entire country (6). According to the Iranian Ministry of Health and Medical Education (MOHME), all activities related to donation and transplantation were halted in March 2020 and then resumed again.

2. Objectives

The aim of this study was to determine the donation and transplantation activities before and after COVID pandemic in Iran.

3. Methods

This retrospective study used the questionnaire designed by Ahmed et al. (11) to compare the deceased organ donation and transplant activities between two specific 9-month periods, March to December 2020 and the same length of time of the last 2 years (2018 - 2019). The survey assessed rates of donation after brain death before and after COVID-19 in a 9-month period. Organ donation system in Iran is donation after brain death.

Questionnaires were sent by email to chief executives of organ procurement units (OPU). From all OPUs in Iran, 15 OPUs chose to participate in western, northern, southern, eastern, middle, southeastern, northwestern, northeastern, southeastern regions of Iran. The questionnaire included the numbers of brain death confirmations, family consents for donation, organ recoveries, solid organs transplanted, cause of brain death, and the new experience of remote working of organ procurement staff after COVID-19.

We also compared the rate of potential donor (a patient whose clinical condition is suspected to fulfill brain death criteria (12)) and eligible donor (the diagnosis of brain death is confirmed, and there are no previously known contraindications to donation (12)) during the two time intervals.

The summary of results for the continuous variables is presented as numbers and percentages for variables. The median (± IQR) changes in continuous outcome variables between two interval times were assessed with Wilcoxon non-parametric test. A P-value less than 0.05 was considered as statistically significant. All data were analyzed using SPSS16 software.

4. Results

The median numbers of organ donations, potential donors, family consents, and marginal donors were dramatically decreased after COVID-19 pandemic. These variables between the two time intervals are compared in Table 1.

Table 1. Number of Organ Donations and Transplantations during the First 9 Months of COVID-19 Outbreak Compared to the Average Number Performed in the Same Period of Time in the Last 2 Years (2018 - 2019)
VariablesDec 2018-March 2019 (Number)March-Dec 2020 (Number)
Brain death confirmations409332
Number of organ donations34384
Number of potential donors361192
Family consents214133
Number of marginal donors11285

Additionally, the medians of organ donations, potential donors, family consents, and marginal donors during the two time intervals were investigated. The Wilcoxon test revealed significant changes between the medians of organ donations (5.6 ± 0.95 vs. 11.86 ± 2.15, P = 0.0187), potential donors (12.8 ± 2.43 vs. 24.06 ± 4.19, P = 0.005), and family consents (8.86 ± 1.93 vs. 14.12 ± 2.52, P = 0.002) during 2020 and average of 2018-2019 years. In addition, there was a significant change between median of eligible donors during the two time periods (2.5 ± 0.53 vs. 3.98 ± 0.63, P = 0.009).

The largest reduction was seen in tissue transplants (62%) during two time intervals. Similar decreases of various magnitudes were seen in liver (48%), kidney (48%), and heart (36%) transplants in two time intervals without a significant impact on new waitlist additions. Non-urgent organ transplantations such as pancreas, small bowel, and lung were suspended in these centers. Guidelines were designed in an organ‐specific manner.

Kidney, liver, and heart donor transplant volumes underwent a noticeable decrease after COVID 19 pandemic (Figure 1).

Figure 1. Number of kidney, liver, heart, and tissue transplantations during Dec 2018 - Mar 2019 period compared to Apr - Dec 2020 period

In spite of head trauma rate changing significantly in two time intervals (median 10.06 ± 2.41 vs. 6.2 ± 2.15, P = 0.05), the other cause of brain death did not change significantly during the two time intervals. Brain death by suicide was increased by 14.44% during the COVID-19 pandemic compared to 2018 - 2019 period (Table 2).

Table 2. The Number and Causes of Brain Death During Two Time Intervals
Cause of Brain DeathAverage period of March-Dec 2018 - 2019March-Dec 2020
Trauma17895
Heart attack 8159
Suicide913
Drug abuse2925
Anoxia136
Tumor1517
Other157

5. Discussion

The impact of the SARS-CoV-2 pandemic on donation and transplantation system was unprecedented. Since the number of COVID‐19 patients is dramatically increasing, all transplantation strategies adapt their protocols in relation to the risk of viral transmission (13). Similar to other countries, in Iran, deceased donation and transplantation programs significantly changed their routine protocols and halted performing all types of transplantations, and all OPUs’ activities were suspended in March 2020.

In updated guidelines after COVID-19 in Iran, epidemiological, clinical, and laboratory assessment of all potential deceased donors and testing all recipients and donors for COVID-19 were recommended. All donor and recipient candidates in the COVID‐19 period were referred for SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) testing or computed tomography (CT) imaging of the chest without evidence of COVID‐19, and all transplantations with a positive RT‐PCR were canceled. Provinces with high burden of COVID-19 infection had reductions in donation and transplantation volume compared to the same period in 2018 - 2019. OPU directors reported an increase in remote referral responses; this was consistent with the study by Ahmed et al. (11) reporting that most programs in some OPUs had changed to telephone consultation for follow-up.

In our study, family consent decreased by 32% in 2020 compared to the same period in 2018 - 2019. Also, four OPU centers had increased telephonic approaches for family consent. According to pervious studies, the first step for family consent is eye contact and face-to-face interactions (14). Phone interview with families and not having face-to-face consultations might negatively affect the results of family consent. Similarly, Ahmed et al. (11) reported that organ authorization in the USA decreased by 11% after COVID-19 pandemic due to telephonic approaches with donor families for both initial contact and follow-up correspondence. Gain et al. (15) showed that the acceptance rates on the telephone were lower than face-to-face interviews during COVID-19 period.

According to this study, there was a remarkable decline (75.52%) in deceased donation during the two time intervals. Due to COVID-19, the rate of eligible donors significantly decreased. These changes reveal that COVID-19 pandemic has had a strong impact, reducing organ donation and transplantation.

In our study, the number of marginal donors and rate of actual and potential donors decreased. One of the reasons for this issue might be the restrictions on the age of donors. Hence, the criteria for marginal donors changed, and the maximum age for kidney donation was reduced to 60 years without having any risk factors. Liver transplants were received only from brain death cases, and donation from alive individuals was cancelled. Similarly, in the UK, the maximum age for deceased organ donor was reduced to 60 years at first and then increased to 75 years following reduced rate of COVID-19 infection (8).

In this study, the largest reduction was seen in tissue transplantation, and all types of deceased donor transplantation volumes dramatically decreased after COVID-19.

In the COVID-19 period in Canada, heart transplants were only performed in patients with critical conditions, although small bowel transplants were suspended (16).

Our results showed that the number of organ donations due to head trauma significantly decreased in 2020 compared to the average period of 2018 - 2019. According to our results, the suicide rate increased in 2020 compared to the average period of 2018 - 2019.

One of the reasons for the decreased brain death rate seems to be the decreased number of intercity travels and remote working due to pandemic restrictions. On the other hand, the increase in suicide events in the mentioned period is probably due to the negative psychological effects of COVID-19.

There was a decrease in transplantation events during the COVID-19 pandemic worldwide (8, 11, 13, 17). As COVID-19 is still a serious public health risk, OPUs need to develop strategies to address challenges in various sectors to improve outcomes of donation, particularly among those requiring urgent life-saving intervention (18).

The impact of COVID-19 pandemic on donation and transplantation is unprecedented, with our results showing a significant reduction in donation and transplantation. Accordingly, it is necessary to develop appropriate protocols and establish new strategies to evaluate organ donation so as to ensure the safety of recipients and medical staff.

Acknowledgements

Footnotes

References

  • 1.

    Kumar D, Manuel O, Natori Y, Egawa H, Grossi P, Han SH, et al. COVID-19: A global transplant perspective on successfully navigating a pandemic. Am J Transplant. 2020;20(7):1773-9. doi: 10.1111/ajt.15876. [PubMed: 32202064]. [PubMed Central: PMC7228301].

  • 2.

    Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814-20. doi: 10.1056/NEJMoa1211721. [PubMed: 23075143].

  • 3.

    Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17(3):181-92. doi: 10.1038/s41579-018-0118-9. [PubMed: 30531947]. [PubMed Central: PMC7097006].

  • 4.

    Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020;395(10223):470-3. doi: 10.1016/S0140-6736(20)30185-9. [PubMed: 31986257]. [PubMed Central: PMC7135038].

  • 5.

    Habibzadeh P, Stoneman EK. The Novel Coronavirus: A Bird's Eye View. Int J Occup Environ Med. 2020;11(2):65-71. doi: 10.15171/ijoem.2020.1921. [PubMed: 32020915]. [PubMed Central: PMC7205509].

  • 6.

    Raoofi A, Takian A, Akbari Sari A, Olyaeemanesh A, Haghighi H, Aarabi M. COVID-19 Pandemic and Comparative Health Policy Learning in Iran. Arch Iran Med. 2020;23(4):220-34. doi: 10.34172/aim.2020.02. [PubMed: 32271594].

  • 7.

    NHS Blood and Transplant. COVID-19 Bulletin 3. NHS Blood and Transplant. 2020.

  • 8.

    Manara AR, Mumford L, Callaghan CJ, Ravanan R, Gardiner D. Donation and transplantation activity in the UK during the COVID-19 lockdown. Lancet. 2020;396(10249):465-6. doi: 10.1016/S0140-6736(20)31692-5. [PubMed: 32798484]. [PubMed Central: PMC7426101].

  • 9.

    Cheung CY, Pong ML, Au Yeung SF, Chak WL. Impact of COVID-19 Pandemic on Organ Donation in Hong Kong: A Single-Center Observational Study. Transplant Proc. 2021;53(4):1143-5. doi: 10.1016/j.transproceed.2021.02.016. [PubMed: 33752902].

  • 10.

    Qu Z, Oedingen C, Bartling T, Schrem H, Krauth C. Organ procurement and transplantation in Germany during the COVID-19 pandemic. Lancet. 2020;396(10260):1395. doi: 10.1016/S0140-6736(20)32213-3. [PubMed: 33129390].

  • 11.

    Ahmed O, Brockmeier D, Lee K, Chapman WC, Doyle MBM. Organ donation during the COVID-19 pandemic. Am J Transplant. 2020;20(11):3081-8. doi: 10.1111/ajt.16199. [PubMed: 32659028]. [PubMed Central: PMC7404840].

  • 12.

    Westphal GA, Garcia VD, Souza RL, Franke CA, Vieira KD, Birckholz VR, et al. Guidelines for the assessment and acceptance of potential brain-dead organ donors. Rev Bras Ter Intensiva. 2016;28(3):220-55. doi: 10.5935/0103-507X.20160049. [PubMed: 27737418]. [PubMed Central: PMC5051181].

  • 13.

    Angelico R, Trapani S, Manzia TM, Lombardini L, Tisone G, Cardillo M. The COVID-19 outbreak in Italy: Initial implications for organ transplantation programs. Am J Transplant. 2020;20(7):1780-4. doi: 10.1111/ajt.15904. [PubMed: 32243677].

  • 14.

    Ghobadi O, Etemadi A, Latifi M, Najafizadeh K. Ten Recommendations on Approaching Next of Kin for Consenting Organ Donation; or How Did We Manage to Increase Consent Rates by 64%? Transplantation. 2020;104(S3):S230. doi: 10.1097/01.tp.0000699576.73732.d0.

  • 15.

    Gain P, Thuret G, Loup Pugniet J, Rizzi P, Acquart S, Le Petit JC, et al. Obtaining cornea donation consent by telephone. Transplantation. 2002;73(6):926-9. doi: 10.1097/00007890-200203270-00017. [PubMed: 11923694].

  • 16.

    Ahn C, Amer H, Anglicheau D, Ascher NL, Baan CC, Battsetset G, et al. Global Transplantation COVID Report March 2020. Transplantation. 2020;104(10):1974-83. doi: 10.1097/TP.0000000000003258. [PubMed: 32243281]. [PubMed Central: PMC7188045].

  • 17.

    Loupy A, Aubert O, Reese PP, Bastien O, Bayer F, Jacquelinet C. Organ procurement and transplantation during the COVID-19 pandemic. Lancet. 2020;395(10237):e95-6. doi: 10.1016/S0140-6736(20)31040-0. [PubMed: 32407668]. [PubMed Central: PMC7213957].

  • 18.

    Cholankeril G, Podboy A, Alshuwaykh OS, Kim D, Kanwal F, Esquivel CO, et al. Early Impact of COVID-19 on Solid Organ Transplantation in the United States. Transplantation. 2020;104(11):2221-4. doi: 10.1097/TP.0000000000003391. [PubMed: 32675741]. [PubMed Central: PMC7406203].

  • Copyright © 2021, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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