Comparison of the Hemodynamic Effects of Pretreatment with Crys-talloids versus Crystalloids plus Ephedrine during Spinal Anesthesia for Caesarean Section.

AUTHORS

M Khooshideh 1 , * , MH Heidari 2

1 Associate Professor, Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.

2 Associate Professor, Department of Anatomy, School of Medicine,Shahid Beheshti University of Medical Sciences, Tehran, Iran.

How to Cite: Khooshideh M, Heidari M. Comparison of the Hemodynamic Effects of Pretreatment with Crys-talloids versus Crystalloids plus Ephedrine during Spinal Anesthesia for Caesarean Section., Shiraz E-Med J. Online ahead of Print ; 10(2):59-65.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 10 (2); 59-65
Published Online: April 1, 2009
Article Type: Research Article
Received: July 31, 2008
Accepted: February 11, 2009
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Abstract

Background: Prevention of hypotension during spinal anesthesia for cesarean section avoids maternal and fetal side effects. The aim of this study was to compare the effects of the com-bination of ephedrine crystalloid and prehydration with crystalloid alone on maternal blood pressure and neonatal outcome during cesarean section under spinal anesthesia.

Method: We enrolled 72 full term women weighing between 50 and 75 Kg, classified as ASA I, scheduled for elective caesarean section under spinal anesthesia. Participants were ran-domly allocated to either the ephedrine or crystalloid group. After arrival in the operating room and intravenous (IV) access, 10 ml/Kg of ringer solution was infused 10-15 minutes before the initiation of the spinal block, but in the ephedrine group, an additional 10mg of ephedrine was added to the solution for infusion. In the crystalloid group, a placebo was added to the solution.

Results: Hypotension occurred in 55.6% of patients in the crystalloid group and in 25% of patients in the ephedrine group. The difference between the two groups was found to be statistically significant (P = 0.008), however, there was no significant difference in mean systolic blood pressure between the two groups (105.61 7.13 in crystalloid group vs. 107.89 9.84 in ephedrine group). Apgar scores in newborns were above 8 in both groups.

Conclusion: Prophylactic ephedrine given by infusion in combination with crystalloid was more effective than crystalloid prehydration in the prevention of hypotension during spinal anesthesia for elective caesarean section.

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© 2009, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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