Effect of Opium Addiction on Perioperative Needs to Inotropic Agents in Coronary Artery Bypass Surgery: a Case-Control Study


S Khademi ** , +

How to Cite: Khademi S. Effect of Opium Addiction on Perioperative Needs to Inotropic Agents in Coronary Artery Bypass Surgery: a Case-Control Study, Shiraz E-Med J. Online ahead of Print ; 13(1):20500.


Shiraz E-Medical Journal: 13 (1); 5-12
Published Online: January 1, 2012
Article Type: Research Article
Received: October 21, 2011
Accepted: October 22, 2011


Methods and Material: 62 male patients up to 75 yrs old scheduled for elective on-pump CABG with ejection fraction>40% were assigned to two groups according to DSM- IV, TR: Opium dependent and nondependent patients. Anesthesia induced and maintained similarly in all patients. During the perioperative period blood pressure(BP),heart rate (HR, central venous pressure (CVP),cardiac output (co),systemic vascular resistance (SVR) ,type and length of inotropes used and the frequency of intra aortic balloon pump (IABP) insertion were monitored and recorded . Paired sample t-test, Independent sample t- test and Chi-Square test were used to compare variables among two groups.

Result: Demographic data showed no significant difference in age, body mass index (BMI), preoperative hemoglobin, ejection fraction (EF) and number of grafts in two groups. Also there was no significant difference regarding the incidence of cardiovascular risk factors and mean blood pressure(MBP). The findings indicated no significant difference in the fre-quency of inotrope usage[23(74.1%) vs. 25(80.6%); p=0.381] and frequency of IABP insertion [2(6.4%) vs. 3(9.6%); p=0.187] between two groups . But the lenght of the need to inotropes in opium dependent patients was significantly lower in comparison with nonde-pendent patients (26.8 9.9 vs. 36.1 17.45; p=0.042).

Objective: to compare the need to inotropic agents in opium dependent (OD) and non de-pendent (NOD) patients during the perioperative period in patients undergoing coronary artery bypass graft (CABG) surgery.

Conclusion: Although the length of the need to inotropic support in non opium dependent was longer as compared to opium dependent patients, frequency of inotrope need and specific inotrope usage and also frequency of IABP insertion was not different between the two groups.

Full Text

Full text is available in PDF

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.