Effect of Zinc Supplementation on Inflammatory Markers in Women with Polycystic Ovary Syndrome.

AUTHORS

F Pourteymour Fard Tabrizi 1 , * , B Alipoor 2 , AR Ostadrahimi 3 , M Mehrzad Sadagiani 4

1 Masters Student

2 Assistant professor, Section of Nutrition. Faculty of Health and Nutrition,

3 Associate Professor. Section of Nutrition, Nutrition Research Center

4 Assistant Professor. Section of Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

How to Cite: Pourteymour Fard Tabrizi F, Alipoor B, Ostadrahimi A, Mehrzad Sadagiani M. Effect of Zinc Supplementation on Inflammatory Markers in Women with Polycystic Ovary Syndrome., Shiraz E-Med J. 2011 ; 12(1):30-38.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 12 (1); 30-38
Published Online: January 1, 2011
Article Type: Research Article
Received: May 24, 2010
Accepted: September 11, 2010
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Abstract

Abstract: Background: Polycystic ovary syndrome, as a low-grade chronic inflammatory state, may stimulate the immune response, increasing inflammatory factors such as C-reactive pro-tein (CRP) and Interleukin 6 (IL-6) on one hand and zinc, another effective anti-inflammatory agent, on the other. The aim of this study is to evaluate the effect of zinc on inflammatory markers in women with polycystic ovary syndrome. Patients and Methods: In a randomized, double-blind, and placebo controlled clinical trial, sixty patients with polycystic ovary syndrome were randomly divided into two groups, each group received one of the following daily supplement for eight weeks; group Zn: 50 mg elemental zinc (n = 30), and group P: Placebo (n =30). Fasting serum zinc levels, inflammatory markers, systolic-and diastolic blood pressure, anthropometric indices, and nutritional intake were measured at the baseline and the end of 8th week. Results: Results indicate that after eight weeks of supplementation, mean value of nutri-tional intake, anthropometric indices, and systolic-and diastolic blood pressure did not change significantly in the two groups. Zinc supplementation had significant effects in increasing serum Zn (p < 0.05) and in decreasing serum hs-CRP and IL-6 levels (p < 0.05). There were no significant changes in the levels of these parameters in the placebo group. Conclusions: The findings of the present study indicate that zinc supplementation may be considered as an inexpensive adjunct to treatments in patients with polycystic ovary syndrome in the hope of reducing cardiovascular disease risk factors, particularly inflam-mation.

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© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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