Antimicrobial Susceptibility Patterns of Salmonella Typhi From Ki-gali, Rwanda.

AUTHORS

R Ashok 1 , * , K Peter 2 , N Joselyne 3 , N Emma 4

1 Senior Microbiologist, Microbiology Unit, Department of Laboratory, King Faisal Hospital, Rwanda

2 Unit supervisor, Microbiology Unit, Department of Laboratory, King Faisal Hospital, Rwanda

3 Technician, Microbiology Unit, Department of Laboratory, King Faisal Hospital, Rwanda

4 Laboratory Manger, Department of Laboratory, King Faisal Hospital, Rwanda

How to Cite: Ashok R, Peter K, Joselyne N, Emma N. Antimicrobial Susceptibility Patterns of Salmonella Typhi From Ki-gali, Rwanda., Shiraz E-Med J. Online ahead of Print ; 11(3):20394.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 11 (3); 117-121
Published Online: January 1, 2010
Article Type: Research Article
Received: October 22, 2009
Accepted: January 29, 2010
READ FULL TEXT

Abstract

Background: Salmonellosis is a major health problem, especially in developing countries like Rwanda. Salmonella typhi infects only human and human transmission occur through feaco-oral route. Moreover, species are becoming resistant to the commonly used antibiotics.

Objective: The aim of the present study is to know antimicrobial susceptibility patterns with special reference to multidrug resistance Salmonella enterica serovar Typhi and reduced susceptibility to nalidixic acid

Materials and Methods: A total 69 S.typhi isolated of King Faisal hospital, Kigali, Rwanda from stool and blood specimens were included in the study. Antimicrobial susceptibility was done by using Kirby-Bauer disc diffusion method.

Results: There was decreased susceptibility was observed in Chloramphenicol, Ampicillin, Amoxycillin/Calvvlanic acid, Tetracycline, Cotrimoxazole and Nalidixic acid. These were sig-nificant increase in the multidrug resistant salmonella typhi (MRST) from 9.1% to 25% re-spectively between 2007 and 2008. All the isolates were 100% sensitive to Ceftriaxone, Levofloxacin and Ciprofloxacin

Conclusion: Typhoid fever has been endemic in Kigali. Decreased susceptibility towards nalidixic is obsevered which gives us alarm for treatment failure towards fluoroquinolones. The antibiotic sensitivity pattern is changing and resistant cases are emerging due to inap-propriate use of antibiotics.

Full Text

Full text is available in PDF

© 2010, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
COMMENTS

LEAVE A COMMENT HERE: