Th1 Cytokine Profiles in Hepatitis C Virus Infected Patients and Their Contribution to Inflammatory Responses


M Najafizadeh 1 , N Farhadi 2 , * , B Sarkari 3

1 PhD Candidate, Department of Microbiology and Immunology, Azerbaijan Medical University, Baku, Republic of Azerbaijan

2 PhD Candidate, Department of Physiology, Baku State University, Baku, Republic of Azerbaijan

3 Assistant Professor, Department of Immunology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

How to Cite: Najafizadeh M, Farhadi N, Sarkari B. Th1 Cytokine Profiles in Hepatitis C Virus Infected Patients and Their Contribution to Inflammatory Responses, Shiraz E-Med J. Online ahead of Print ; 8(1):22-27.


Shiraz E-Medical Journal: 8 (1); 22-27
Published Online: January 1, 2007
Article Type: Research Article
Received: October 7, 2006
Accepted: December 25, 2006


Background: Th1 cytokines are required for host antiviral immune responses. However little is known about the production and progression of cytokines in hepatitis C virus (HCV) infected patients. The aim of this study was to assess the serum levels of Th1 cytokines and also their association with inflammatory indicators in HCV-infected and normal individuals.

Method: Fifty four HCV-infected patients along with thirty one healthy controls were selected using the sequential sampling method. Serum levels of interleukine-2 (IL-2), interferon-gamma (IFN-y) and tumor necrosis factor-alfa (TNF-a) was determined in all the precipitants by enzyme-linked immunosorbent assay (ELISA). Moreover serum levels of alanine aminotransferase (ALT), aspartat aminotransferase (AST), alkaline phosphatase (ALP), C-reactive protein (CRP) and rheumatoid factor (RF) were also determined in both patient and control groups.

Results: The results showed that serum levels of IFN-y, TNF-a and IL-2 were higher in HCV-infected patients than controls group but the difference was significant only for TNF-a (p<0.05). A positive correlation was found between the serum level of TNF-a and IL-2 in patient group (p<0.05).

Conclusions: TNF-a is the main mediator of the acute inflammatory responses to microbial infections and in our study serum level of TNF-a in HCV-infected patients was higher than healthy subjects. Positive correlation of serum TNF-a and IL-2 levels in HCV-infected patients may contribute to the role of innate immunity in stimulating the adaptive immune responses, thus suggests role of TNF-a in antibody production.

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