The Relationship between Lichen Planus and Hepatitis C in Birjand, Iran


R Ghaderi 1 , * , Z Makhmalbaf 2

1 Associate professor and Chairman, Department of Dermatology No. 2, Birjand University of Medical Sciences, Birjand, Iran

2 Director of Health Care Center No. 2, Birjand University of Medical Sciences, Birjand, Iran

How to Cite: Ghaderi R, Makhmalbaf Z. The Relationship between Lichen Planus and Hepatitis C in Birjand, Iran, Shiraz E-Med J. Online ahead of Print ; 8(2):72-79.


Shiraz E-Medical Journal: 8 (2); 72-79
Published Online: April 1, 2007
Article Type: Research Article
Received: October 25, 2006
Accepted: January 30, 2007


Background: The reported prevalence of hepatitis C virus (HCV) infection in patients with lichen planus (LP) shows variations in different regions.

Objective: This study was conducted to determine the frequency of hepatitis C in Iranian patients with lichen planus at Imam reza hospital, city of Birjand, Iran.

Methods: In this case-control study, seventy three cases of lichen planus, 31 (42.5%) women and 42 (57.5%) men were diagnosed. They were recruited after obtaining a verbal consent to participate in the study and after confirmation of the diagnosis by histology. In the patients, liver function tests were performed and the patients were screened for the presence of anti-HCV antibodies. We used the prevalence of HCV antibody among 150 volunteer blood donors (age and sex matched) for comparison as the control group. An enzyme-linked immunosorbent assay (ELISA) was used to determine the presence of anti- HCV antibodies in all subjects in both groups.

Results: All patients with lichen planus had normal liver function tests. Three (4.1%) out of the 73 lichen planus group, and 1 (0.67%) out of the 150 control group were seropositive for anti-HCV Antibody. This was significantly higher than that of the control group (p < 0.05).

conclusion: The results of this study suggest that a relationship exists between hepatitis C virus infection and lichen planus among Iranian patients from Birjand.

Full Text

Full text is available in PDF

© 2007, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.