Effect of Measles Virus Antibodies from Breast Milk of Nursing Mothers on Seroconversion of Children After Measles Vaccination


CF Odoemele 1 , NCD Ukwandu 1 , * , FD Adu 1 , OPG Nmorsi 2 , OO Omotade 3

1 Department of Virology, College of Medicine University, College Hospital, PMB 5116, Ibadan, Nigeria

2 Department of Zoology, Faculty of Natural Sciences, Ambrose Alli University, PMB 14, Ekpoma, Nigeria

3 Institute of Child Health, University College Hospital, Ibadan, Nigeria

How to Cite: Odoemele C , Ukwandu N, Adu F, Nmorsi O, Omotade O. Effect of Measles Virus Antibodies from Breast Milk of Nursing Mothers on Seroconversion of Children After Measles Vaccination, Shiraz E-Med J. 2006 ; 7(2):e93678.


Shiraz E-Medical Journal: 7 (2); e93678
Published Online: April 01, 2006
Article Type: Research Article
Received: May 14, 2019
Accepted: April 01, 2006


The effects of measles virus (MV) antibodies (abs) in the sera and breast milk of nursing and lactating mothers on sericonversion to measles vaccination was studied. Three hundred and ninty six samples were collected each from sera and breast milk of nursing mothers and corresponding number of finger prick prevaccination sera samples on filter paper from their children were tested for MV abs. Eighty (20.2%) mothers had measles haemagglutination inhibition (HI) abs in their sera and 88(27.2%) had MV HI abs in their breast milk. Eight (2.0%) of the children who had prevaccination MV abs in their sera were all from MV ab negative mothers. Forty-four (37.0%) who came back for post vaccination sera seroconverted while 76 (63.3%) gave a low seroconversion rate of 37.0%. Results showed that MV abs in either sera or breast milk of mothers did not interfer with MV vaccination in their children. The low seroconversion rate obtained was due to low vaccine potency with titers ranging between (log10-1.0 – log10-2.5) TCID/per dose. This was beside other non-specific antiviral substances exhibited virus neutralizing activity.



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