Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy

AUTHORS

Saeedeh Salimi 1 , Anoosh Naghavi 1 , Zahra Zakeri 2 , Sima Nabizadeh 3 , Farzaneh Farajian-mashhadi 4 , Mahnaz Sandoughi 2 , *

1 Department of Clinical Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2 Department of Internal Medicine, Clinical Research Development Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3 Department of English, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

4 Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

How to Cite: Salimi S , Naghavi A, Zakeri Z, Nabizadeh S , Farajian-mashhadi F, et al. Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy, Zahedan J Res Med Sci. 2013 ; 15(10):e92822.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (10); e92822
Published Online: March 12, 2013
Article Type: Research Article
Received: October 28, 2012
Revised: December 12, 2012
Accepted: January 15, 2013
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Abstract

background : Systemic lupus erythematosus (SLE) is a multisystem disease with unknown etiology. We hypothesized that insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene may influence the development and/or progression of SLE and lupus nephritis.
Materials and Methods : In a crass sectional case-control study, genomic DNA from 106 SLE patients and 103 healthy controls matched for sex, age, and ethnicity, were genotyped for the (I/D) polymorphism of ACE gene by polymerase chain reaction (PCR). Comparison of quantitative variants between two groups was assessed by student t-test and association between qualitative variables was analyzed by the chi-square or Fisher exact tests. 
Results : The frequency of DD genotype in SLE patients was significantly higher than control group (25.5 % vs. 14 %), and the risk of SLE was 2.2 times greater in subjects with DD genotype than the individual by DI and II genotypes (OR, 2.2 [95% CI, 1.1 to 4.4] p=0.023). The distribution of D allele in SLE patients was significantly higher (p=0.021) compare to controls (47 and 36.4, respectively). The Risk of nephropathy in SLE patients with DD genotype was three times more than other genotypes (OR), 3 [95% CI, 1.1 to 8] p=0.027].
Conclusion: This study demonstrated that ACE DD genotype acts as a risk factor on SLE and Lupus nephropathy in an Iranian population. 

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