Vibrio cholerae and Changing of Microbial Resistance Patterns in Sistan and Balouchestan Province


alireza salimi khorashadi 1 , * , S. Mahdi Tabatabaee 2 , Alireza Amirabadi 2 , Shahla Roudbar-Mohamadi 3

1 Department of Parasitology, Research center for infectious and tropical disease, Zahedan, Iran

2 Health Center, Zahedan University of Medical sciences, Zahedan, Iran

3 Department of Mycology, Tarbiat Modares University, Tehran, Iran

How to Cite: salimi khorashadi A, Tabatabaee S M, Amirabadi A, Roudbar-Mohamadi S. Vibrio cholerae and Changing of Microbial Resistance Patterns in Sistan and Balouchestan Province, Zahedan J Res Med Sci. 2012 ; 14(8):e93284.


Zahedan Journal of Research in Medical Sciences: 14 (8); e93284
Published Online: June 19, 2012
Article Type: Research Article
Received: November 25, 2011
Accepted: May 31, 2012


Background : Cholera is a diarrheal disease in tropical regions that exclusively affects humans. This study conducted to compare changes in antibiotic resistance patterns in 2011with that of the period of 2008-2010 on cholera patients in the area covered by Zahedan University of Medical Sciences.
Materials and Methods : In this descriptive study, rectal swab samples within Blair working environment of all suspected patients of each region were sent to the laboratory of each region and diagnostic procedures were performed, and Antimicrobial Susceptibility Testing (AST) was performed trough distribution methods on agar disk. Disks were prepared from Iranian Padtan Teb Company and the results were evaluated and reported using NCCLS table and the other experimental antimicrobial susceptibility determination tables.
Results : In this study, antimicrobial susceptibility testing was performed on 81 positive samples including Ogawa or Inaba during 4 years. The samples in 2008, 2009 and 2010 followed a similar susceptibility pattern and all these samples were resistant to co-trimoxazole, nalidixic acid and ampicillin, had intermediate sensitivity to furazolidone, were sensitive to tetracycline, ciprofloxacin, doxycycline, erythromycin and susceptibility pattern of cases in 2011 included sensitivity to erythromycin and ciprofloxacin and have shown no sensitivity to doxycycline and tetracycline and halo of their lack of growth were placed in the intermediate range.
Conclusion : Vast border between the province and Afghanistan and Pakistan and inevitability of the occurrence of regional cholera epidemics may cause a serious problem in control of the possible epidemics and recalls the need to perform drug sensitivity tests during epidemics before any remedial action more than ever.


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