Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat

AUTHORS

Hossein Najafzadeh 1 , * , Hassan Morovvati 2 , Babak Mohammadian 3 , Mohammad Razijalali 3 , S.Mahsa Poormoosavi 4

1 Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

2 Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3 Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

4 Faculty of Veterinary Medicine, Shahid Chamran University,Ahvaz, Iran

How to Cite: Najafzadeh H , Morovvati H, Mohammadian B, Razijalali M, Poormoosavi S. Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat, Zahedan J Res Med Sci. 2012 ; 14(7):e93314.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 14 (7); e93314
Published Online: December 07, 2011
Article Type: Research Article
Received: August 27, 2011
Accepted: September 29, 2011
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Abstract

Background: Atorvastatin is a lipid-lowering drug used to treat hyperlipidemia. Phenobarbital is the inductor of cytochrome enzymes. This study examined the interfering effect of simultaneous consumption of these drugs on the biochemical and pathological changes in rat’s kidney.
Materials and Methods: Drugs were administered to 4 groups of Wistar rats (8 per group) for 15 days as follows: normal saline, atorvastatin, atorvastatin phenobarbital and phenobarbital alone. After anesthesia, blood was taken from the heart and serum was removed to measure myoglobin, creatinine, BUN, sodium, potassium and uric acid. After easy kill of rats, kidneys were removed and tissue sections were prepared through the conventional method of pathologic sections preparation and they were stained with Hematoxylin-Eosin, and pathological changes were examined by light microscopy.
Results: The simultaneous use of atorvastatin with phenobarbital significantly increased serum myoglobin of rats compared with control group. Pathological changes in the group receiving atorvastatin and phenobarbital simultaneously was observed with a greater intensity.
Conclusion: Phenobarbital can reduce renal toxicity of atorvastatin.

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  • © 2012, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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