The Comparative Effect of Herbal Extract of Vitagnus and Mefenamic Acid on Primary Dysmenorrhea

AUTHORS

Fatemeh Shobeiri 1 , fatemeh zeraati 2 , * , Zahra Mansouri 3 , Maliheh Araghchian 2 , Mansour Nazari 4

1 Department of Midwifery, Research Center for Child & Maternity Care (RCCMC), School of Nursing & Obstetrics, Hamadan University of Medical Sciences, Hamadan, Iran

2 Department of Pharmacology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran

4 Department of Medical Entomology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

How to Cite: Shobeiri F, zeraati F, Mansouri Z, Araghchian M, Nazari M. The Comparative Effect of Herbal Extract of Vitagnus and Mefenamic Acid on Primary Dysmenorrhea, Zahedan J Res Med Sci. 2012 ; 14(5):e93459.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 14 (5); e93459
Published Online: August 17, 2011
Article Type: Research Article
Received: October 17, 2010
Accepted: November 16, 2010
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Abstract

Background: Dysmenorrhea is among the factors disrupting women's social activities. Selecting medicines with lower side effects are preferred. The objective of this study is to compare between the effect of herbal extracts of Vitagnus and Mefenamic Acid on the primary dysmenorrhea and menstrual bleeding in female students of the University of Medical Sciences, Hamadan in 2009-2010.   
Materials and Methods: This Study was carried out on 80 students with primary dysmenorrhea as two-way blind clinical experience. The participants were randomly divided into three groups of receiving Vitagnus drop, Mefenamic Acid capsule, and placebo drop. Severity of dysmenorrhea was assessed using pain severity measurement tool during a cycle before and two cycle later taking the medicine. Data was analyzed using SPSS-16 Software.
Results: Individual characteristics of the samples were similar. Mean pain intensity and menstrual bleeding in a cycle before the treatment beginning had no significant differences in the three groups, but in two cycles after the treatment beginning, there was a significant difference between the three and the effect of Vitagnus drop was more effective than Mefenamic Acid capsule in mitigating dysmenorrhea (p=0.0001). The two medicines (mefenamic acid and Vitagnus) were effective in reducing menstrual bleeding (p<0.05).
Conclusion: Vitagnus drop and mefenamic acid resulted in mitigating dysmenorrhea and the effect of Vitagnus was more than mefenamic acid. The two medicines (mefenamic acid and Vitagnus) were effective in reducing menstrual bleeding. Accordingly, Vitagnus herbal medicine can be used as the effective and safe medicine for dysmenorrhea

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