The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis

AUTHORS

Tayebeh Sanchooli 1 , Hamidreza Mahmoudzadeh-Sagheb 1 , * , Hamidreza Mahmoudzadeh-Sagheb 1 , Mohammad Hashemi 2 , Mohammad Ayub Rigi-Ladiz 3

1 Department of Histology, Research Center for Infectious Diseases and Tropical Medicine, Boo-Ali Hospital, Zahedan University of Medical Sciences, Zahedan, Iran

2 Department of Clinical Biochemistry, Cellular and Molecular Research Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3 Department of Periodontology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

How to Cite: Sanchooli T, Mahmoudzadeh-Sagheb H , Mahmoudzadeh-Sagheb H , Hashemi M, Rigi-Ladiz M A. The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis, Zahedan J Res Med Sci. 2012 ; 14(3):e93544.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 14 (3); e93544
Published Online: March 18, 2012
Article Type: Research Article
Received: December 20, 2011
Accepted: January 12, 2012
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Abstract

Background: Chronic periodontitis is an inflammatory disease that causes rapid destruction of the tissues supporting the teeth. Genetic and environmental factors are involved in its occurrence. It has been suggested that IL-6 promoter gene polymorphism could affect the severity of chronic periodontitis. This study has examined the relationship between IL-6 (-174G/C) gene polymorphism and chronic periodontitis.
Materials and Methods:  In this case-control study, 100 patients with chronic periodontitis and 100 healthy individuals referring to the clinic of Zahedan Dental School were evaluated. Two ml of peripheral blood was taken from these people. After DNA extraction through salting out method, IL-6 gene polymorphism was determined through T-ARMS-PCR technique using specific primers. The data were analyzed by chi-square test and p<0/05was considered significant.
Results: The frequency of genotypes CC, GC, GG was respectively 61%, 35% and 4% in patients and respectively 67%, 31% and 2% in the control group. The frequency of G and C alleles was respectively 78.5% and 21.5% in the patient group, and respectively 82.5% and 17.5% in control group. No statistically significant difference was observed between the two groups in frequency of genotypes and alleles.
Conclusion: This study showed no correlation between IL-6-174 G/C gene polymorphism and chronic periodontitis.

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  • © 2012, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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