Effect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats

AUTHORS

Shima Mojtahedi 1 , * , MohammadReza Kordi 2 , Masoud Soleimani 3 , seyed ebrahim hosseini 4

1 MSc of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.

2 Associate professor of Exercise Physiology, School of Physical Education and Sport Science, University of Tehran, Tehran, Iran.

3 Assistant professor of Hematology, Tarbiat Modares University, Tehran, Iran.

4 MSc of Exercise Physiology, Sabzevar Islamic Azad University,Razavi Khorasan, Iran

How to Cite: Mojtahedi S, Kordi M, Soleimani M, hosseini S E. Effect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats, Zahedan J Res Med Sci. 2012 ; 14(2):e93575.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 14 (2); e93575
Published Online: February 29, 2012
Article Type: Research Article
Received: January 26, 2012
Accepted: February 08, 2012
READ FULL TEXT

Abstract

Background: One of the most specific miRNA of the brain is miR-124 which has been detected in the hippocampal area. This microRNA through suppression of some target genes, cause the stem cell to be changed into the neuron. The aim of this study was to identify the effect of exercise intensity on the expression of miR-124.

 Materials and Method: Eighteenadult male Wistar rats were selected as subjects. The animals randomly divided into 3 groups of control (n=6) and runner (n=6). In low intensity group (n=6) animals daily, were allowed to run on treadmill with an intensity of about 35-40% of maximum oxygen consumption, daily for 30 minutes, of 2 weeks period. In high intensity group (n=6) the subjects were run in the same conditions but with an intensity of about 70-75% maximum oxygen consumption. After 24 hours of the last session of exercise, the animals were killed. Changes in expression analyzed using the quantitave RT-PCR technique.

Results: Statistical analysis by one-way ANOVA showed a statistically significant association between the intensities of exercise and elevated expression of miR-124 in the exercise group at significant level of p≤0.05.

Conclusion: To sum up, expression of miR-124, in the hippocampus of adult rats, is associated with exercise intensity and running forcefully in comparison with lower intensity, in which leads to robust changes in some mechanisms that involve in exercise- induced neurogenesis. [ZJRMS, 2012 14(2): 16-20]

Fulltext

The full text of this article is available on the PDF file.

References

  • 1.

    The References of this article are available on the PDF file.

  • © 2012, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
    COMMENTS

    LEAVE A COMMENT HERE: