Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat

AUTHORS

Fatemeh Arbabi-Kalati 1 , * , Mehran Mesgari-Abbasi 2 , Narjes Akbari 3

1 Assistant Professor of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran

2 Instructor of Research, Drug Applied Research Center, Tabriz University of Medical Sciences and Health Services, Tabriz, Iran.

3 Resident of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

How to Cite: Arbabi-Kalati F, Mesgari-Abbasi M, Akbari N. Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat, Zahedan J Res Med Sci. 2010 ; 12(4):e94283.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 12 (4); e94283
Published Online: August 19, 2010
Article Type: Research Article
Received: April 10, 2010
Accepted: May 11, 2010
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Abstract

  Background : Oral cancer is one of the ten most frequent cancers worldwide. Reactive oxygen species (ROS), may play a key role in human cancer development. Inflammation occurs in cancers and increases oxidative stress agent COX2 over expression in oral premalignant lesions. Several studies showed COX2 inhibitors con improve antioxidant system. The aim of this study is the evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat.

  m aterials and Method : Fifty male Sprague Dawley adult 3-3.5 months' old rats were used as animal model in this study. The tongue SCC was induced by a daily administration of 30 ppm 4-nitroquinoline 1-oxide (4-NQO), in drinking water, for 8 months. The rats in case groups received dietary or topical CCB. CCB powder was added to powdered basal diet and e ach rat received CCB with daily food. Adhesive Gels were prepared by mixing the base plasty with oral paste including two different dose of CCB. These groups include: group A» 30 ppm 4-NQO treatment group B» 30 ppm 4-NQO+dietary CCB treatment group C» 30 ppm 4-NQO+topical low dose CCB treatment group D» 30 ppm 4NQO+high dose topical CCB treatment and group E» dietary CCB as control+water.

  Results : Statistical analysis showed significant differens between groups in total antioxidant, hemoglobin and nutrophilic count.  

Conclusion : Topical CCB can use as adjuvant treatment for premalignant lesions

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