Antibiotic resistance of Neisseria gonorrhoeae isolated from gonorrhoeae patients

AUTHORS

Mohammad Bokaeian 1 , * , Mazhar Iqbal-Qureshi 2 , Soroush Dabiri 2

1 Assistant Professor, Dept. of Laboratory Sciences, School of Paramedical Sciences, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

2 MSc, Dept. of Laboratory Sciences, School of Paramedical Sciences, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

How to Cite: Bokaeian M , Iqbal-Qureshi M, Dabiri S. Antibiotic resistance of Neisseria gonorrhoeae isolated from gonorrhoeae patients, Zahedan J Res Med Sci. 2010 ; 12(2):e94309.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 12 (2); e94309
Published Online: May 14, 2010
Article Type: Research Article
Received: September 26, 2009
Accepted: December 12, 2009
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Abstract

Background: The objective of this study was to determine antibiotic susceptibility and penicillinase production by Neisseria gonorrhoeae strains isolated from gonorrhoeae patients in Zahedan.

  Materials and methods: In a descriptive study during 2005-2008 years, 400 suspected patients were studied by history review, medical examination, gram staining and culture in Thayer-Martin medium. Antibiotic susceptibility and penicillinase tests of isolated strains were done by disk diffusion method and aciodometric method, respectively.

  Results: Cultures were positive in 77(19.2%) patients. The resistanat rate against antibiotics were as follow: penicillin (79.2%), ciprofloxacin (53.2%), ceftriaxone(3.8%), spectinomycin(2.5%), cefixime(12.9%), co-trimoxazole(93.5%), tetracycline(88.3%) and gentamicin(29.8%). In the meanwhile, 83.1 percent of penicillin resistant isolates produced penicillinase enzyme.

  Discussion: Ceftriaxone, spectinomycin and cefixime are the sole antibiotics that could be considered as selective drugs. Quinolones which were regarded as an effective group of antibiotics recently have lost their importance. Resistance against other antibiotics is rapidly developing, thus, conducting experimental tests and determination of minimum inhibitory concentration and clinical trial studies at fixed intervals can contribute to diagnosis of resistance of gonococci and rapid and successful treatment of their infections in Zahedan region.

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