Comparison of effect of Domperidone and placebo on human milk production

AUTHORS

L sekhavat 1 , * , fatemeh zarei 1 , Sedighah Akhavan Karbasi 2

1 Dept of Midwifery and Genicology, Faculty of Medicine, Shahid Sadooghy University of Medical Sciences and Health Services, Yazd, Iran.

2 Dept of Pediatrics, Faculty of Medicine, Shahid Sadooghy University of Medical Sciences and Health Services, Yazd, Iran.

How to Cite: sekhavat L, zarei F, Akhavan Karbasi S . Comparison of effect of Domperidone and placebo on human milk production, Zahedan J Res Med Sci. 2007 ; 9(4):e94773.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 9 (4); e94773
Published Online: June 17, 2008
Article Type: Research Article
Received: December 22, 2007
Accepted: April 07, 2007
READ FULL TEXT

Abstract

Background:Lactation failing is one of the leads to infants weight loss and illness. Vary degree of
success have been reported with many strategies to increase milk production when it is failed. This
study was investigated the effect of Domperidone in augmentation milk production
Materials and Methods: In a double blind placebo controlled trial 48 mothers that their infants
were under grow square and it was due to mothers milk not enough, randomly was divided to two
groups : 24 received Domperidone 10mg TDS orally for 14 days and 24 received placebo ( the
same shape) TDS orally for 14 days. Milk volume was measured the day before study on day 7, 14
and one week after study; and serum prolactin level was measured the day before study, day 14 and
one week after the study. SPSS 11.5 software was used to analyze the results with Q square test and
T student test; and P< 0.05 was significantly difference.
Results: Data obtained from two group of study indicated treatment with Domperidone
increased the volume of milk amount 48.5 ml compared 8 ml in treatment with placebo.(P= 0.008)
also serum prolactin was raised 116.4 ng/ml in Domperidone group compared with 4ng/ml in
placebo group (P=0.001)
Discussion: Domperidone is an effective drug in milk production increasing and serum
prolactin.

Fulltext

The full text of this article is available on the PDF file.

References

  • 1.

    The References of this article are available on the PDF file.

  • © 2007, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
    COMMENTS

    LEAVE A COMMENT HERE: