The comparison of two combination antibiotic [(OAB-T) VS (OAB-F)] regimen trophy in peptic ulcer and dyspepsia patients

AUTHORS

Ali Bahari 1 , * , S. Kazem Nezam 1 , Mehrbod Karimi 2 , K Firoozeh 1

1 Dept of Internal Medicine, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

2 Dept of Pathology, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

How to Cite: Bahari A, Nezam S K, Karimi M, Firoozeh K. The comparison of two combination antibiotic [(OAB-T) VS (OAB-F)] regimen trophy in peptic ulcer and dyspepsia patients, Zahedan J Res Med Sci. 2007 ; 9(4):e94775.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 9 (4); e94775
Published Online: October 10, 2007
Article Type: Research Article
Received: August 19, 2007
Accepted: September 22, 2007
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Abstract

Background: Eradication of H. Pylori has an important role in curing peptic ulcer and
dyspepsia. Several therapeutic regimens have been offered for eradication of H. Pylori. There are
several reports of resistance of H. Pylori to metronidazole in Iran, so other therapeutic regimens
have been offered. We compared Furazolidone versus Tetracycline, in quadruple regimen
[Omeprazole-Amoxicillin-Bismuth subcitrate-Tetracycline (OAB-T) vs. [Omeprazole-Amoxicillin-
Bismuth subcitrate-Furazolidone (OAB-F)].
Materials and Methods: In a clinical trial study we treated 109 H. Pylori infected patients with
dyspepsia in Zahedan Khatam-ol-Anbia Hospital in two therapeutic groups. The first group
received Omeprazole 20 mg BID, Bismuth subcitrate 200 mg Q6h, Amoxicillin 1 gr Q12h,
Furazolidone 100 mg Q12h. The second group received Omeprazole 20 mg BID, Bismuth
subcitrate 200 mg Q6h, Amoxicillin 1 gr Q12h, Tetracycline 500 mg Q 12h.
Results: There were 49 patients in OAB-F group and 51 patients in OAB-T group. H. Pylori
eradication rate based on H. Pylori fecal Ag Test negativity was 85.7% and 80.4% in OAB-F &
OAB-T groups respectively.
Discussion: Furazolidone-based regimen is effective in H. Pylori eradication. With respect to
low price and availability of Furazolidone, Furazolidone- based Quadruple therapy is an
acceptable regimen in communities with high metronidazole resistance.

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