Comparing the Effect of Pethedine, Dexamethasone and Placebo on Preventing Post-operation Shivering


Hossein KKhoshrang 1 , * , A Parvizi 1 , Soudabeh Haddadi 1 , A Heidarzadeh 2

1 Dept of Anesthesiology, Faculty of Medicine, Rasht University of Medical Sciences and Health Services Gilan, Iran.

2 Dept of Social Medicine, Faculty of Medicine, Rasht University of Medical Sciences and Health Services, Gilan, Iran.

How to Cite: KKhoshrang H, Parvizi A, Haddadi S, Heidarzadeh A. Comparing the Effect of Pethedine, Dexamethasone and Placebo on Preventing Post-operation Shivering, Zahedan J Res Med Sci. 2007 ; 9(3):e94804.


Zahedan Journal of Research in Medical Sciences: 9 (3); e94804
Published Online: September 04, 2007
Article Type: Research Article
Received: August 27, 2007
Accepted: August 30, 2007


Background: Post-operation shivering is very common and followed by many problems such as
increased oxygen consumption, blood pressure, intracranial and intraocular pressure, and postoperation
pain. Therefore, prevention of shivering is important especially in elderly and ischemic
heart disease patients. The goal of this study was comparing the effect of Pethedine (Meperidin),
Dexamethasone and Placebo on prevention of shivering.
Material and Methods: This double blind clinical trial study was carried out on 114 patients of
ASA class I and II who were candidates for elective abdominal surgery under general anesthesia.
The patients were randomly divided into three groups including those who received Pethedine (P),
Dexamethasone (D) and Placebo (N). Induction and maintenance of anesthesia for all patients were
similar. Temperature of patients was measured in 4 steps: before induction, before extubation, in
the beginning of recovery and the end of recovery. Five minutes before the ending of the surgery
0.3mg/kg of Pethedine, 0.1mg/kg of Dexamethasone and 3ml of saline 0.9% were injected to groups
P, D and N respectively. IN recovery all patients were controlled for visible shivering. 25mg of
Pethedine was injected intra venously while shivering. All data were statistically analyzed by SPSS
software and ANOVA and chi square tests.
Results: There were no significant differences among three mentioned groups regarding of
gender, age and duration of surgery. 18 cases (47.4%) in group N had post-op shivering. Whereas,
in group D only 7 cases (18.4%) had shivering and the difference was significant (P value=
0.0001). Also in group P just 3 cases (7.9%) had shivering that the difference from Placebo group
was significant (P value= 0.0001). But the difference between groups P and D was not significant
too (P value= 0.155).
Conclusion: The present study showed that Pethedine and Dexamethasone are effective drugs for
preventing the post-op shivering in elective abdominal surgery.


The full text of this article is available on the PDF file.


  • 1.

    The References of this article are available on the PDF file.

  • © 2007, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.