The survey of Teucrium Polium toxicity effect on liver and serum lipoproteins in normoglycemic male rats

AUTHORS

Mohamad Shahraki 1 , * , Hamideh Mirshekari 2 , Elham Shahraki 2 , E Miri Moghadam 3 , MJ Palan 4

1 Paramedicine Dept, Faculty of Medicine, Zahedan University of Medicine Sciences and health services, Zahedan, Iran.

2 Khatam Hospital, Faculty of Medicine, Zahedan University of Medicine Sciences and health services, Zahedan, Iran.

3 Imonohematologt Dept, Faculty of Hematology, Faculty of Medicine, Zahedan University of Medicine Sciences and health services, Zahedan, Iran.

4 English Dept, Faculty of Medicine, Zahedan University of Medicine Sciences and health services, Zahedan, Iran.

How to Cite: Shahraki M, Mirshekari H, Shahraki E, Miri Moghadam E, Palan M. The survey of Teucrium Polium toxicity effect on liver and serum lipoproteins in normoglycemic male rats, Zahedan J Res Med Sci. 2006 ; 8(3):e94885.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 8 (3); e94885
Published Online: September 01, 2006
Article Type: Research Article
Received: January 17, 2006
Accepted: July 13, 2006
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Abstract

Background: Liver is an important organ in carbohydrates and fatty acids oxidation and to clear
toxic agent. Teucrium Polium is an herbal medicament used in traditional medicine without
considering its side effects. The aim of this survey was to study the toxic effects of Teucrium Polium
on serum levels of liver enzymes, lipoproteins and blood sugar.
Material &Methods: The survey was carried out on 20 normoglycemic male rats with body
weight, ranging from 200-280 gr that were divided randomly in two equal groups randomly. Test
group were given Teucrium Polium extract (D=1/09) through gavages for 4 weeks. Control group
received the same volume of tap water. At the end of the course, liver enzymes, serum lipoproteins
and blood sugar were measured. Data obtained were analyzed by SPPS software v.12 and mean
values were compared with student t-test. The results were expressed as mean ± SD and statistical
difference considered meaningful if P<0.05.
Results: the results of this survey showed that AST, ALT, and ALP, values of test group were
significantly higher than that of the control group but other factors, which were evaluated in test
and control group, did not show significant difference.
Conclusion: This survey revealed Teucrium Polium use in male rats led to liver Toxicity by
increasing liver enzyme value.

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